松花粉辅助紫杉醇联合铂类化疗的增效减毒作用

Synergism and attenuation effects of Pini Pollen on paclitaxel and cisplatine chemotherapy

目的研究松花粉对紫杉醇联合铂类(paclitaxel and cisplatin,TP)方案化疗有无减毒和增效作用。方法取人肺癌H460细胞株制备的移植瘤裸鼠48只,按瘤体积均衡原则分为模型组、松花粉600、300、150 mg/kg三个剂量+TP方案化疗组、单用TP方案化疗组、单用松花粉600、300、150 mg/kg三个单剂量组,每组6只。各组给予相应的药物后以裸鼠的体重、进食量、抑瘤率、血液学和肝肾功能等为评价指标,全面评价松花粉对TP化疗方案有无增效和减毒作用。结果模型动物给予TP方案化疗的同时灌胃给予松花粉(150、300、600 mg/kg)可明显提高单用TP化疗方案的抑瘤率,抑制化疗药物引起的体重减轻和摄食量的减少、抑制化疗引起的白细胞降低和肝肾功能的损伤。结论 TP方案化疗的同时给予松花粉具有明显的增效减毒作用。

Objective To investigate the synergism and attenuation effects of Pini Pollen on paclitaxel and cisplatin（ TP） chemotherapy in model mice. Methods Forty-eight model nude mice with H456 cell line xenograft were divided into 8 groups： model group,TP chemotherapy group,Pini Pollen（ 150,300 and 600 mg/kg） group and TP chemotherapy plus Pini Pollen（ 150,300 and 600 mg/kg） group. The tumor inhibition rates,body weight,food intake,hematology and blood biochemistry indexes were selected to evaluate the synergism and attenuation effects of intragastric administration of Pini Pollen（ 150,300,600 mg/kg） on TP chemotherapy. Results Compared with the TP chemotherapy group,the tumor inhibition rates,body weight,food intake,white blood cell count were increased and liver and kidney function damage were alleviated significantly in the TP chemotherapy plus Pini Pollen groups. Conclusions Pini Pollen has a significant synergism and attenuation effects on TP chemotherapy.