摘要
峨眉唐松草碱(methoxyadiantifoline 5μmol/L)显著降低大白鼠离体灌流心脏缺血再灌注损伤所致心室纤颤的发生率、延长窦性心律时间、减少心肌细胞中乳酸脱氢酶的释放及丙二醛的生成,显示其具有保护心肌及抑制脂质过氧化作用,效果与维拉帕米近似。
Methoxyadiantifoline ( MAF) is a new alkloid isolated from Thalictrum Omeience W.T.Wang.During 3 min reperfusion after 10 min of coronary ligation, MAF 5 μmol/L significantly decreased the incidence of isolated rat hearts with ventricular arrhythmias ( VF and VT ) . It delayed the onset of ventricular fibrillation and shortened its duration and markedly prolonged the time of normal sinus rhythm. It also significantly decreased the release of LDH from the myocardium in isolated rat hearts. In addition , MAF 5 μmol/L could decrease the heart rate and coronary resistance. The results suggest that MAF possessed protective effects on the reperfusion injury in isolated rat hearts.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第5期337-341,共5页
Chinese Pharmacological Bulletin
关键词
峨眉唐松草碱
心肌缺血
再灌注损伤
Methoxyadiantifoline
Verapamil
Myocardium ischemia and reperfusion
Arrhythmia
Lactate dehydrogenase
Lipid peroxides
