硝酸咪康唑缓释凝胶治疗念珠菌性阴道炎的疗效观察

Observation on the efficacy of miconazole nitrate sustained release gel in the treatment of candidal vaginitis

目的观察硝酸咪康唑缓释凝胶治疗念珠菌性阴道炎的疗效。方法 95例妊娠合并念珠菌性阴道炎患者,随机分成对照组(39例)和治疗组(56例)。对照组患者应用硝酸咪康唑栓治疗,治疗组患者应用硝酸咪康唑缓释凝胶治疗。比较两组患者临床效果、不良反应发生情况、脱落情况及真菌学治愈情况。结果两组患者脱落率比较差异无统计学意义(P>0.05)。治疗组患者痊愈率为72.92%(35/48)、总有效率为95.83%(46/48),均高于对照组患者的48.48%(16/33)、81.82%(27/33),差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。两组均未发生严重不良反应。治疗组患者真菌学治愈率为85.42%(41/48),高于对照组的66.67%(22/33),差异具有统计学意义(P<0.05)。结论对念珠菌性阴道炎患者采用硝酸咪康唑缓释凝胶治疗可提高其临床效果,并且具有较高的安全性,在临床治疗中具有比较重要的意义。

Objective To observe the efficacy of miconazole nitrate sustained release gel in the treatment of candidal vaginitis. Methods A total of 95 pregnant patients with candidal vaginitis were randomly divided into control group（39 cases） and treatment group（56 cases）. The control group was treated with miconazole nitrate suppositories, and the treatment group was treated with miconazole nitrate sustained release gel. Comparison were made on clinical effect, occurrence of adverse reactions, expulsion and mycological cure condition between two groups. Results Both groups had no statistically significant difference in expulsion rate（P〉0.05）. The treatment group had cure rate as 72.92%（35/48）, total effective rate as 95.83%（46/48）, which were all higher than 48.48%（16/33） and 81.82%（27/33） in the control group, and their difference was statistically significant（P〈0.05）. Both groups had no statistically significant difference in incidence of adverse reactions（P〉0.05）. Both groups had no severe adverse reactions. The treatment group had higher mycological cure rate as 85.42%（41/48） than 66.67%（22/33） in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Miconazole nitrate sustained release gel can improve the clinical effect of patient with candidal vaginitis with high safety, and it is of great of importance in clinical treatment.