小剂量米非司酮在子宫肌瘤临床治疗中的应用价值评价

Evaluation on application value of low dose mifepristone in the treatment of uterine fibroids

目的探讨小剂量米非司酮在子宫肌瘤临床治疗中的应用价值。方法 140例子宫肌瘤患者,随机分为对照组和观察组,每组70例。对照组采用大剂量米非司酮治疗,观察组采用小剂量米非司酮治疗,比较两组患者的临床疗效、子宫肌瘤体积、血清激素变化及不良反应。结果观察组治疗总有效率为95.71%,稍高于对照组的91.43%,两组比较差异无统计学意义(P>0.05)。治疗3个月后,两组患者的瘤体体积、促卵泡激素(FSH)、促黄体生成素(LH)、孕酮(P)、雌二醇(E2)比较,差异无统计学意义(P>0.05)。观察组患者的恶心、潮热、阴道干燥等不良反应发生率为5.71%,明显低于对照组的14.29%,差异具有统计学意义(P<0.05)。结论小剂量米非司酮在子宫肌瘤临床治疗中应用效果良好,能够明显缩小瘤体,促进血清激素水平恢复正常,且不良反应轻微,具有积极的临床意义。

Objective To investigate the application value of low dose mifepristone in the treatment of uterine fibroids. Methods A total of 140 uterine fibroids patients were randomly divided into control group and observation group, with 70 cases in each group. The control group received high dose mifepristone, and the observation group receive low dose mifepristone. Comparison were made on clinical efficacy, uterine fibroid volume, serum hormone changes and adverse reactions in two groups. Results The observation group had a little higher total treatment effective rate as 95.71% than 91.43% in the control group, and the difference was not statistically significant（P〉0.05）. After 3 months of treatment, both groups had no statistically significant difference in tumor volume, follicle stimulating hormone（FSH）, luteinizing hormone（LH）, progesterone（P）, estradiol（E2）（P〉0.05）. The observation group had obviously lower incidence of adverse reactions of nausea, hot flashes, vaginal dryness as 5.71% than 14.29% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Low dose mifepristone shows excellent application effect in clinical treatment of uterine fibroids, and can obviously reduce the tumor volume, promote serum hormone levels back to norma wtih slight adverse reactions. It contains positive clinical significance.