盐酸羟考酮缓释片与盐酸曲马多缓释片治疗中度癌痛疗效比较

Effect Comparion of Oxycodone Hydrochloride Prolonged-release Tablets and Tramadol Hydrochloride Sustained-release Tablets in the Treatment of Moderate Cancer Pain

目的比较盐酸羟考酮缓释片与盐酸曲马多缓释片治疗中度癌痛的疗效及不良反应。方法将80例中度癌痛患者随机分为治疗组和对照组,每组40例,治疗组口服盐酸羟考酮缓释片,对照组口服盐酸曲马多缓释片,治疗2周后评价疗效及不良反应。结果 80例患者均可进行客观疗效评价和不良反应观察。治疗后NRS评分治疗组比对照组低(P<0.05);治疗组CR率为32.5%,明显高于对照组的12.5%(P<0.05);治疗组便秘发生率40.0%,明显高于对照组12.5%(P<0.05)。结论盐酸羟考酮缓释片治疗中度癌痛患者优于盐酸曲马多缓释片。

Objective To investigate the efficacy and safety of oxycodone hydrochloride prolonged-release tables and tramadol hydrochloride sustained-release tablets in the treatment of moderate cancer pain.Methods A total of 80 patients with moderate cancer pain were randomly divided into the treatment group and the control group,each with 40 patients.The treatment group was treated with oxycontin,and the control group was treated with tramadol hydrochloride,the efficacy and toxicities were evaluated.Results Eighty patient were given an objective evaluation of therapeutic response and toxicities.NRS score in the treatment group was lower than that in the control group(P<0.05).The CR rate of the treatment group was higher than that of the control group(32.5% vs 12.5%,P<0.05).The incidence of constipation was significantly higher in the experimental group than in the control group(40.0% vs 12.5%,P<0.05).Conclusion Oxycodone hydrochloride in relieving moderate pain is superior to tramadol hydrochloride zyban.