DNA修复基因XPC多态性与乳腺癌易感性关系的Meta分析

Meta Analysis of Association Between Polymorphism of XPC and Susceptibility of Breast Cancer

目的利用Meta分析探讨DNA修复基因着色性干皮病基因组C(XPC)Ala499Val多态性与乳腺癌易感性的关系。方法通过Pub Med、Embase、Web of Science和中国生物医学文献数据库,检索XPC基因多态性与乳腺癌易感性相关的文献。由2位研究者独立筛选文献并提取相关数据资料,采用STATA 12.0软件进行Meta分析。结果按照纳入标准,最终纳入Meta分析的研究有9项。Meta分析结果显示:XPC Ala499Val在纯合子模型[(Val/Val)vs(Ala/Ala)]和隐性模型[(Val/Val)vs(Ala/Val+Ala/Ala)]下与乳腺癌易感性之间存在相关性(纯合子模型:OR=1.21,95%CI:1.02~1.45;隐性模型:OR=1.23,95%CI:1.05~1.43)。结论 XPC Ala499Val多态性与乳腺癌易感性之间存在相关,但上述结论尚需要大样本量的研究予以验证。

Objective To study the association between xeroderma pigmentosum group C(XPC) Ala499 Val polymorphism and susceptibility of breast cancer by meta-analysis.Methods Literatures were searched from Pub Med,Embase,Web of Science and Chinese Biomedical Literature databases.The literatures were independently screened by two investigators,and Meta analysis was performed by using STATA 12.0 software.Results A total of 9 studies were included in the final Meta analysis according to the inclusion criteria.The results of Meta analysis showed that,XPC Ala499 Val was associated with increased susceptibility of breast cancer under the homozygous model(OR=1.21,95% CI:1.02-1.45) and the recessive model(OR=1.23,95% CI:1.05-1.43).Conclusion XPC Ala499 Val polymorphism may contribute to the breast cancer risk,which needs further validation in single large studies.