肿瘤医院医院感染病原菌分布及耐药性分析

Analysis of the Distribution and Drug Resistance of Pathogenic Bacteria in Tumor Hospital Hospital

目的了解肿瘤医院肿瘤患者医院感染病原菌分布及耐药性分析,为临床合理用药提供有效的依据。方法收集我院2015年1月至2016年12月临床科室送检的标本,回顾性分析其临床分布特点及耐药性。结果临床送检细菌培养标本共计12 972份,所送标本检出病原菌4 623株,阳性率为35.6%。其中革兰阴性菌2 829株,占61.2%;革兰阳性菌1 188株,占25.7%;酵母样真菌606株,占13.1%。主要病原菌为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌、金黄色葡萄球菌和白色假丝酵母菌。革兰阴性杆菌对亚胺培南、美洛培南、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦的敏感率均达到80.0%以上。革兰阳性球菌对替考拉宁、夫西地酸、万古霉素敏感率均达到100%。结论肿瘤医院患者院内分离的病原茵及耐药特征与其他医院有所不同,且病原菌的耐药率较高,应加强并做好细菌耐药监测工作,合理使用抗生素。

Objective To understand the distribution and drug resistance of pathogenic bacteria in tumor patients in tumor hospital and to provide an effective basis for the rational use of drugs. Methods Collected specimens from the clinical department of our hospital from January 2015 to December 2016. The clinical distri-bution characteristics and drug resistance were analyzed retrospectively. Results A total of 12972 specimens of bacterial culture were collected from the clinical samples, and 4623 strains separated, with a positive rate of 35. 6 % . The gram - negative bacteria were 2827 strains, which accounted for 61.2% . The gram - positive bacteria were 1185, 25.7%. Yeast fungus 606, 13. 1 % . The main pathogenic bacteria are Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus and white Candida. The sensitive rates of gram - negative bacilli were above 80.0% for yampernan, meropinan, cefoperazone/ sulbatan, peracillin/tazobaltan. The sensitive rate of the gram - positive coccus aureus was 100% for the replacement of the substitute, the fusidic acid and vancomycin. Conclusion Tumor hospital patients in the separation of pathogenic bacterium and drug resistance characteristics are different from other hospitals, and pathogen resis-tance is higher, should be strengthened and bacterial drug resistance monitoring, rational use of antibiotics.