复旦大学生物医学研究院表观遗传研究回顾

Retrospect of Institute of Biomedical Sciences of Fudan University on epigenetics research

一般认为,表观遗传学是研究由非基因序列变化造成可遗传性状的科学,其所涵盖的调控形式广泛参与细胞生命活动的各个过程,并且在许多疾病的发生发展过程中具有重要的调控作用。人类基因组计划之后,表观遗传研究的一系列发现让人们意识到遗传信息调控的复杂性和精细性,该领域成为21世纪生命科学与医学领域最为活跃的研究方向之一。复旦大学生物医学研究院(Institute of Biomedical Sciences,Fudan University,简称"IBS")依托于上海医学院,自建院之初就将"医学表观遗传学"列入重点研究方向,经过12年的发展,该方向上已经产生了一大批在国际上具有高影响力的原创性成果。这些成果对提升我国在世界范围内表观遗传领域的影响具有重要意义,同时对复旦大学生物医学相关学科的建设和人才培养做出了重要贡献。本文主要对复旦大学生物医学研究院在表观遗传领域取得的一批具有代表性的研究成果进行了总结与回顾。

Epigenetics is the study of heritable traits that are not involved in the changes in DNA sequences. It has been widely recognized that epigenetics plays multiple regulatory roles in diverse cellular activities and is associated with the occurrence and development of a variety of diseases. Following the human genome project （HGP） ,discoveries in the field of epigenetics reveal the complexityand accuracy of genetic regulation. Institute of Biomedical Sciences （IBS） , which is affiliated with Fudan University Shanghai Medical School,has been attaching great importance to “Medical Epigenetics” since the establishment of IBS. In the past 12 years, a number of influential discoveries in medical epigenetics have been made,raising China^s status in the field of epigenetics and contributing greatly to the disciplinary construction and talent cultivation of biomedical-related disciplines in Fudan University. In this review？a list of accomplishments in epigenetics in IBS were summarized.