摘要
在家兔心肌肌膜和人工生物膜脂质体上,牛磺酸显著抑制氧自由基发生系统(FeCl_3和抗坏血酸)所引起的脂质过氧化物丙二醛的增加,其抑制作用呈剂量依赖和时间依赖关系。本结果证实牛磺酸具有抗氧化作用,在膜水平上直接起到自由基清除剂作用。
In the rabbit's myocardial sarcolemma and artificial biomem-brane-liposomes, the lipid peroxidation caused by free radical gene-arting system ( FeCls & ascorbic acid ) was significantly inhibited by taurine at the concentractions of 5~20 m mol/L, and the inhibition effects of taurine were both dose and time-dependent. The results showed that taurine had an antioxidation effects and served as a scavenger of free radicals at the level of membrane.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第5期354-356,共3页
Chinese Pharmacological Bulletin
基金
国家科委"七五"攻关资助项目
关键词
牛碘酸
脂质过氧化
心肌肌膜
家兔
Taurine
Lipid peroxidation
myocardial sarcolemma
Liposome
