IL-37在慢性肾脏疾病患者中表达及临床意义

Expression and clinical significance of interleukins-37 in patients with chronic kidney disease

目的探讨慢性肾脏病(CKD)患者和肾病综合征(NS)患者血浆白细胞介素37(IL-37)水平的变化及临床意义。方法选取2016年9-11月中山大学附属东华医院收治的CKD患者57例(CKD组)和NS患者13例(NS组)作为研究对象,并将CKD组分为CKD 1期组、CKD 3期组和CKD 5期组,同时选取健康体检者22例作为健康对照组。采用酶联免疫吸附试验夹心法检测血浆IL-37水平,对检测结果进行统计分析。结果 CKD组和NS组血浆IL-37水平明显高于健康对照组,差异有统计学意义(P<0.01);CKD 1期组、CKD 3期组和CKD 5期组血浆IL-37水平差异无统计学意义(P>0.05);CKD组和NS组治疗后血浆IL-37水平低于治疗前,差异有统计学意义(P<0.01);CKD患者血浆IL-37水平与白细胞、淋巴细胞水平呈正相关。结论 CKD和NS患者血浆IL-37呈高水平表达,对CKD和NS具有很好的辅助诊断价值。

Objective To investigate the level change of interleukin-37（IL-37）and its clinical significance in the patients with chronic kidney disease（CKD）and nephrotic syndrome（NS）.Methods 57 cases of CKD（CKD group）and 13 cases of NS（NS group）in the Affiliated Donghua Hospital of Sun Yat-sen University from September to November 2016 were selected.The CKD group was redivided into the CKD stage 1,stage 3 and stage 5 groups.At the same time 22 individuals undergoing physical examination were selected as the healthy control group.The ELISA sandwich method was adopted to detect the plasma IL-37 level.Then the detection results were statistically analyzed.Results The level of plasma IL-37 in the CKD group and NS group was significantly higher than that in the healthy control group,the difference was statistically significant（P0.01）;the level of plasma IL-37 had no statistical difference among the CKD stage 1 group,CKD stage 3 group and CKD stage 5 group（P0.05）;the plasma IL-37 level after treatment in the CKD group and NS group was decreased compared with before treatment,the difference was statistically significant（P0.01）;the plasma IL-37 level in CKD patients was positively correlated with the WBC and lymphocyte cells levels.Conclusion The patients with CKD and NS have high level expression of plasma IL-37,which might have good auxiliary diagnostic value for CKD and NS.