硒联合疏肝健脾法治疗桥本甲状腺炎的疗效及对T细胞亚群的影响

Clinical effect and influence of combined selenium with soothing liver and activating spleen method on T-lymphocyte subsets in Hashimoto's thyroiditis treatment

目的观察硒联合疏肝健脾法治疗桥本甲状腺炎伴甲状腺功能减退的疗效及对T淋巴细胞亚群的影响。方法选择120例桥本甲状腺炎伴甲状腺功能减退患者,随机均分为A、B和C组,A组采用优甲乐治疗,B组在A组治疗的基础上口服硒酵母片,C组在B组治疗的基础上给予疏肝健脾方,观察3组临床治疗效果及对T淋巴细胞亚群的影响。结果 C组在怕冷、神疲乏力、面目浮肿、食欲减退、体质量增加与大便秘结等症状的改善方面明显优于A组;C组的TSH、TGAb和TPOAb水平明显低于A组,FT3和FT4水平明显高于A组;C组的CD3+、CD4+、CD4+/CD8+水平明显高于A组,CD8+水平明显低于A组,差异均具有统计学意义(P<0.05)。3组患者治疗过程中均未发生明显的不良反应。结论硒联合疏肝健脾法治疗桥本甲状腺炎伴甲状腺功能减退可有效改善患者T淋巴细胞亚群的紊乱,临床治疗效果明显。

Objective To observe the clinical effect and influence of combined selenium with soothing liver and activating spleen method on T-lymphocyte subsets in Hashimoto′s thyroiditis treatment.Methods 120 patients with Hashimoto′s thyroiditis incorporating with hypothyroidism were assigned into group A,B and C.Euthyrox was applied to treat group A,selenium yeast on the basis of euthyrox was used to treat group B,and soothing liver and activating spleen method based on the treatment of group B was rendered to group C.The clinical effect of the groups and the influence on serum T-lymphocyte subsets were observed.Results The improvement of symptoms of coldness feeling,loss of vitality and strength,edema of face,poor appetite,weight gain and constipation in group C was obviously better than that in group A.After the treatment,the levels of TSH,TGAb and TPOAb in group C were obviously lowered when compared with the levels in group A,and the levels of FT3 and FT4 in group C were obviously higher than that in group A;meanwhile,the levels of CD3＋,CD4＋and CD4＋/CD8＋ in group C were also obviously higher than that in group A while the level of CD8＋ was lower than that in group A（P0.05）.No adverse reaction was observed in the 3 groups during the treating process.Conclusion The application of combined selenium with soothing liver and activating spleen method to treat Hashimoto′s thyroiditis incorporating with hypothyroidism could effectively improve patients′T-lymphocyte subsets disorder with obvious clinical effect.