加味银翘方治疗甲型H_1N_1流感病毒感染与奥司他韦等效性随机平行对照研究

Randomized Parallel Controlled Study on the Equivalent of Modified Yinqiao Decoction in the Treatment of Influenza a H_1N_1 Influenza Virus Infection and Oseltamivir Phosphate

[目的]观察加味银翘方治疗甲型H_1N_1流感病毒感染与奥司他韦等效性。[方法]使用随机平行对照方法,将50例门诊患者按随机数字表随机分为两组。对照组25例磷酸奥司他韦,75mg/次,2次/d。治疗组25例加味银翘方(金银花、连翘各15g,杏仁、贯众、桔梗、炙麻黄、淡豆豉、板蓝根各10g,薄荷8g),1剂/d,水煎200m L,早晚口服。连续治疗5d为1疗程。观测临床症状、退热时间、咳嗽消失时间、咽痛消失时间、头痛缓解时间、治愈时间、4d病毒核酸转阴率、不良反应。治疗1疗程,判定疗效。[结果]临床疗效两组间无明显差异(P>0.05)。退热时间、咳嗽消失时间、咽痛消失时间、头痛缓解时间、治愈时间治疗组均少于对照组(P<0.05)。4d病毒核酸转阴率治疗组优于对照组(P<0.05)。[结论]加味银翘方治疗甲型H_1N_1流感病毒感染,疗效满意,与磷酸奥司他韦治疗具有等效性,无严重不良反应,值得推广。

[Objective] To observe the therapeutic effect of modified Yinqiao decoction in the treatment of influenza a H1N1 influenza virus infection. [Methods] Using random parallel control method, 50 outpatients were randomly divided into two groups according to the random number table.25 cases of the control group Oseltamivir phosphate, 75 mg/times, 2 times/d, the treatment group of 25 cases modified Yinqiao Decoction honeysuckle, forsythia each 15g, almond, aspidium, campanulaceae, ephedra,fermented soybean,radix isatidis each 10g, mint 8g）, 1 agent/d, decoction 200mL, sooner or later,oral. Continuous treatment with 5days for 1 courses. Clinical symptoms, fever time, cough disappear time, throat disappear time, headache relief time, cure time, 4d virus nucleic acid negative rate, adverse reaction were observed. Treatment for 1 course, determine the efficacy. [Results] The clinical curative effect of no significant difference between the two groups （P〉0.05）. Fever time, cough disappear time, throat disappear time, headache relief time, cure time of treatment group were less than control group （P〈0.05）. 4d virus nucleic acid negative rate was better than the control group （P〈0.05）. [Conclusion] Modified Yinqiao decoction in the treatment of influenza a H1N1 influenza virus infection is equivalent with oseltamivir phosphate treatment,the effect is satisfactory, no serious adverse reactions, it is worth promoting.