补肺汤联合沙丁胺醇雾化吸入治疗小儿慢性支气管炎(肺气虚弱)随机平行对照研究

Fill the Spray Lung Decoction combined with Inhalation of Salbutamol in the Treatment of Children with Chronic Bronchitis(Feiqi Xuruo) Randomized Controlled Study

[目的]观察补肺汤联合沙丁胺醇治疗小儿慢性支气管炎疗效。[方法]使用随机平行对照方法,将60例住院患者按病历号抽签随机分为两组。对照组30例沙丁胺醇5mg+0.9%氯化钠4m L,4L/min雾化吸入,15~20min/次,2次/d。治疗组30例补肺汤(当归15g,黄芪60g,熟地黄15g,丹参20g,白术15g,半夏、制麻黄各10g,五味子、麦冬、茯苓各15g,蛤蚧6g),水煎150m L,1剂/d,早晚分服;沙丁胺醇治疗同对照组。连续治疗7d为1疗程。观测临床症状、咳嗽、咳痰、动脉血氧分压(PaO_2)、动脉血二氧化碳分压(PaCO_2)、不良反应。治疗1疗程(7d),判定疗效。[结果]治疗组临床控制14例,显效10例,有效4例,无效2例,总有效率93.33%;对照组临床控制8例,显效7例,有效7例,无效8例,总有效率73.33%;治疗组疗效优于对照组(P<0.05)。PaO_2、PaCO_2两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]补肺汤联合沙丁胺醇雾化吸入治疗小儿慢性支气管炎,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the curative effect of invigorating lung soup combined with salbutamol in treatment of chronic bronchitis in children. [Methods] Using random parallel control method, 60 patients were randomly divided into two groups according to the medical record number. The control group consisted of 30 patients with salbutamol, 5mg＋0.9%, sodium chloride, 4mL, 4 L/min inhalation, 15-20 mirdtimes, 2 times/ d. The treatment group of 30 cases of Bufei decoction （angelica 15g, astragalus 60g, radix rehmanniae 15g, salvia 20g, atractylodes 15g, pinellia, ephedra lOg, schisandra chinensis, ophiopogon root, Poria cocos 15g, gecko 6g）, decoction 150mL, 1 Ji/d, sooner or later the service; salbutamol treatment with the control group. Continuous treatment with 7d was the 1 course of treatment. The clinical symptoms, cough and expectoration, arterial oxygen partial pressure （PaO2）, arterial carbon dioxide partial pressure （PaCO2）, and adverse reactions were observed. The course of treatment was 1 （7d）, and the curative effect was determined. [Results] the treatment group 14 cases were clinically controlled, 10 cases were markedly effective, 4 cases effective, 2 cases ineffective, the total efficiency of 93.33%; control group, clinical control 8, markedly effective, 7, effective 7 cases, invalid 8 cases, the total efficiency of 73.33%; the treatment group than the control group （P〈O.05）. PaO2 and PaCO2 were improved in the two groups （P〈0.O1）, and the treatment group was better than the control group （P〈0.01）. [Conclusion] The curative effect of invigorating lung soup combined with salbutamol aerosol inhalation in treating chronic bronchitis in children is satisfactory, and there is no serious adverse reaction. It is worth popularizing.