骨组织细胞与免疫细胞间相互作用的研究进展

Research Progress on the Interactions between Bone Cells and Immune Cells

骨作为一种特殊的结缔组织,是组成骨骼系统的主要部分。成骨细胞的骨形成和破骨细胞的骨吸收作用受到内分泌、神经和免疫系统的调节。其中,骨骼和免疫系统密切相关且共享许多调节分子,如细胞因子和转录因子。骨组织细胞与免疫细胞间的相互调控在骨骼系统和免疫系统中均发挥了重要作用,并产生了一个新兴的交叉学科—骨免疫学。该文综述了近年来骨组织细胞与免疫细胞间的相互调控及作用机制的研究进展并展望了未来该学科的发展方向。

As a special connective tissue, bone is the main part of the composition of the skeletal system. Bone formation of osteoblasts and bone resorption of osteoclasts are regulated by endocrine, nervous and immune systems. Skeletal and immune systems are closely related and share many regulatory molecules such as cytokines and transcription factors. The interactions between bone cells and immune cells play a very important role in skeletal system and immune system. An emerging interdisciplinary subject study on the interactions between bone cells and immune cells is called osteoimmunology. Herein, we reviewed the research progress of interplay and interactions and its underlying mechanism between the two kinds of cells and prospected the future development direction of osteoimmunology.