AP-1的研究进展

Research Progress on AP-1

激活蛋白-1(activator protein-1,AP-1)是细胞内一类转录激活因子,主要由原癌基因编码的蛋白质Jun和Fos组成,以同源或异源二聚体复合物形式结合DNA靶序列,调控靶基因表达。AP-1通过调节靶基因表达来应对多种刺激(包括细胞因子、生长因子、压力及细菌和病毒感染等)对细胞的影响,参与调节细胞增殖、分化、凋亡以及炎症等多种细胞过程。该文就AP-1的结构特点、生物学功能、活性调控及其在医学研究中的应用作一综述。

Activator protein-1（AP-1） is considered as a kind of intracellular transcriptional activator, mainly composed of proto-oncogene encoding protein Jun and Fos, which binds DNA target sequence in the form of homodimer or heterodimer complex, regulating the expression of target genes. AP-1 regulates the expression of target genes in response to the effect of various stimuli on cells, such as cytokines, growth factors, pressure, bacteria and viral infections, and it is also implicated in the regulation of variety of cellular processes, including cell proliferation, differentiation, apoptosis, inflammation and other cellular functions. This review aims to elucidate the structural characteristics, biological function, activity regulation and it＇s application in medical study of AP-1.