SKA2在肿瘤发生发展中的作用及其调控机制

Effects of SKA2 and Its Regulation Mechanism in Tumorigenesis

纺锤体和动粒相关蛋白2(spindle and kinetochore associated 2,SKA2)是2006年首次发现的参与纺锤体与动粒相关复合物组成的重要蛋白质。传统观点认为,SKA2参与细胞周期的调控。新近研究发现,ska2在肿瘤细胞和组织中异常表达,发挥着癌基因的作用,且在不同肿瘤中存在多种调控机制。该文结合我们的实验结果,对SKA2在肿瘤发生、发展中的作用及其调控机制进行综述,为癌基因ska2的深入研究及肿瘤的靶向治疗提供新的思路。

SKA2（spindle and kinetochore associated 2） was initially identified in 2006, and it was an important protein of the spindle and kinetochore associated complex. Previous reports showed that it participated in the regulation of cell cycle progression. Recent studies demonstrated that SKA2 was aberrant expressed in a variety of malignant tumors and played a role of oncogene in cancer. In addition, different mechanisms were involved in the regulation of tumor development. Based on our studies, this paper reviewed the role of SKA2 and its regulated mechanism in the tumorigenesis. It provided a novel idea for the further study of oncogene ska2 and targeted therapy of tumor.