胃癌中长非编码RNA调节网络的研究进展

Progress of Long Non-coding RNA Regulatory Network in Gastric Cancer

长非编码RNA(long non-coding RNA,lnc RNA)是一类长度大于200 nt、因缺少完整的阅读编码框而不编码蛋白质的功能性RNA分子。胃癌是我国常见的恶性肿瘤之一,其发病率仅次于肺癌,居我国第二位。越来越多的证据表明,lnc RNA在转录、转录后和表观遗传水平调控基因的表达及稳定性,参与肿瘤的发生和发展,对于评估癌前病变的发生、判断化疗的疗效和胃癌的预后具有重要意义。该文就近年来关于lnc RNA调节网络对胃癌发生发展机制的作用研究进展作一综述。

Long non-coding RNA（lncRNA） is a kind of functional molecule with length usually more than 200 nt. It can not encode proteins because of lacking a complete reading frame. Gastric cancer（GC） is one of common malignant tumors in our country, whose incidence rate accounts the seconds in all kinds of cancer. More and more accumulated evidences verify that lncRNA participates in the initial and development of GC by regulating gene expression and stability on transcript, post-transcriptional and epigenetic level. It has been already reported that a large number of lncRNA in GC is important in estimating pathological change before cancer, evaluating the curative effect of chemotherapy and prognosis of GC. In this review, we mainly introduce the recent progress of lncRNA regulatory network affects the occurrence and development of GC.