静脉注射不同阿片肽拮抗物抗大鼠烫伤休克效果的比较

COMPARISON OF EFFECTS OF DIFFERENT OPIOID ANTAGONISTS ON SCALD SHOCK IN RATS

在大鼠20%体表面积Ⅲ°烫伤后,立即从静脉分别注射beta-内啡肽抗血清10μl,ICI_(174864) 0.2mg,TRH 2mg,或纳洛酮2mg,随后在1,2,3h再分别给予半量,观察心血管功能指标和存活时间。结果表明,beta-内啡肽抗血清、ICI_(174864)和纳洛酮,均可改善烫伤动物的心功能指标,延缓MAP下降和HR减慢,尤其beta-内啡肽抗血清可显著延长动物的存活时间。TRH在早期能增加烫伤动物的心率,延缓MAP的下降,晚期却加快了MAP的下降,对心功能指标几无改善。这提示beta-内啡肽抗血清、ICI_(174864)和纳洛酮,均有抗烫伤休克的作用;TRH如何适当地应用于抗烫伤休克,有待进一步探讨。

Indexes of cardiovascular function and survival time were obser-vedin rats given the following antagonists respectively after scald injury: anti-p-endorphin serum at 10μl, Naloxone at 2mg, ICI174864 at 0.2mg, or TRH at 2 mg, and half of the doses were administered at 1, 2, 3h after scald. The results showed that the cardiac indexes (dP/dtmax, -dP/dtmax and LVSP)were improved, the decrease of mean arterial pressure ( MAP ) and heart rate ( HR ) were delayed after the injections of anti-p-endorphin serum, naloxone or ICIi748e4, and survival time was significantly prolonged in anti β - endorphin serum group. TRH had little effect on cardiac indexes, MAP and HR were maintained at high level at earlier period, but sharply sloped down in about 210 min after burn. The result suggests that intraventri-cular administration of anti-β-endorphin, naloxone or ICI174864 had much benefit on scald shock, but TRH was uncertain at least in the treatment of scald shock.