摘要
在PPA催化条件下,4-氟邻苯二胺和脯氨酸在微波照射下,以84%的较高收率一步合成得到5-氟苯并咪唑。其化学结构通过核磁共振谱~1HNMR和LC-MS谱图确证。该法极大地简化了实验操作,可广泛应用于类似物的合成,对于高通量筛选此类化合物具有重要帮助。
In the presence of PPA catalyst, 5-fluoro benzimidazole was synthesized in one step at high yield of 84% from 4-fluoro-o-phenylenediamine and proline under microwave irradiation. The chemical structure was confirmed by 1 H NMR and LC-MS spectra. This method greatly simplifies experimental operation, can be widely used in the synthesis of analogues and shows great importance for high throughput screening of those compounds.
出处
《浙江化工》
CAS
2017年第10期8-11,共4页
Zhejiang Chemical Industry
基金
贵州省科技厅联合基金资助项目(NO:黔科合LH字[2015]7531)
关键词
4-氟邻苯二胺
微波
合成
关键中间体
5-氟苯并咪唑
4-fluorobenzene-1,2-diamine
microwave radiation
synthesis
key intermediate
5 -fluoro- 1 H-benzo[ d]imidazole
