小剂量雌激素治疗绝经期妇女慢性疲劳综合症临床研究

Clinical Study on the Treatment of Chronic Fatigue Syndrome in Postmenopausal Women with Low Dose Estrogen

目的:研究小剂量雌激素治疗绝经期妇女慢性疲劳综合症(chronic fatigue syndrome,CFS)的临床疗效。方法:治疗组用小剂量雌激素贴剂治疗绝经期妇女慢性疲劳综合症,对照组用安慰剂进行治疗。治疗前后进行疲劳量表-14(FS-14)评分,并抽血查血清促卵泡生成素(FSH)、雌二醇(Estradiol,E2)。结果:两组治疗后FS-14评分降低,达到改善CSF症状的目的。治疗组患者治疗后的E2含量明显增加,而FSH含量稍降低。结论:小剂量E2贴剂可以有效缓解CFS症状,可达到改善症状的目的。

Objective：To study the clinical effect of low dose estrogen in the treatment of chronic fatigue syndrome（chronic fatigue syndrome, CFS） in postmenopausal women. Methods：The treatment group was treated with low dose estrogen patches in the treatment of postmenopausal women with chronic fatigue syndrome, the control group were treated with placebo. Before and after treatment, the fatigue scale-14（FS-14） score and blood serum were drawn to the serum follicle stimulating hormone（FSH） and estradiol（Estradiol, E2）. Results：After treatment, the CSF score of the two groups was decreased, and the purpose of improving the symptoms of FS-14 was achieved. The content of E2 in the treatment group was significantly increased, while the FSH content was slightly lower.Conclusion：low dose E2 patch can effectively alleviate the symptoms of CFS, can achieve the purpose of improving symptoms.