再发急性脑梗死患者外周血白细胞、中性粒细胞的变化及其意义

Analysis on the Varieties of Peripheral Leukocyte Total Count、the Neutrophile Gyanulocyte Count with Recurrent Acute Cerebral Infarction Patients.

目的:观察患者外周血白细胞总数、中性粒细胞计数与再发急性脑梗死的关系。方法:分析天津市第一中心医院神经内科2015年6月-2015年12月,共82例急性脑梗死患者相关资料,其中32例为再发脑梗死患者,50例为初发脑梗死患者,另外选取同期健康对照者35例,分别测定、比较各组间外周血白细胞总数、中性粒细胞计数的水平差异;并按影像学表现把所有患者脑梗死面积分为大面积、中面积、腔隙性梗死3组,依次各43例、32例、16例,然后比较三组白细胞、中性粒细胞数目大小。对白细胞、中性粒细胞数目进行多因素Logistic回归分析。结果:健康对照者、初发脑梗死患者及再发脑梗死患者的白细胞总数及中性粒细胞计数逐渐增高,且各组间差异有统计学意义(P<0.05);大面积脑梗死组白细胞、中性粒细胞数目大于中面积组(P<0.05),中面积梗死组大于腔隙性梗死组(P<0.05)。多因素回归分析显示,白细胞数目(OR=0.756、95%CI:0.630-0.907、P<0.01),中性粒细胞数目(OR=0.773、95%CI:0.644-0.926、P<0.01)是再发脑梗死的危险因素。结论:外周血白细胞、中性粒细胞数目与脑梗死复发有相关性,是脑梗死再发生的危险因素。

Objective：To observe the relationship of the peripheral leukocyte count,neutrophil cells count with recurrent acute cerebral infarction. Methods：From June 2015 to December 2015, in Tianjin First Center Hospital, the clinical and laboratory data of82 patients diagnosed with ACI were collected. 32 cases with recurrent acute cerebral infarction and 50 cases with initial cerebral infarction and 35 cases with no symptoms. The total count of leukocytrs,count of neutrophil cells and prothrombin time in the blood of each groups were determined,and the differences of the results were compared. And those patients were divided according to the area of infarction into three groups：large area, middle area, lacunar infarction groups; in turn,each of 43 cases,32cases,16 cases. the total number of leukocytrs and neutrophil cells in the blood of each groups were determined,and the differences of the results were compared. The total number of leukocytrs and neutrophil cells were analysed by logistic regression. Results：The consistency of the total count of leukocytrs,count of neutrophil cells among three groups（recurrent group, initial group, normal group）gradually increased and were statistically significant（P〈0.05）. The leukocyte count and the neutrophil gyanulocyte count with the group of large area cerebral infarction increased（P〈0.05）. In the multivariate Logistic regressiont analysis, white blood cell counts（OR=0.756、95% CI：0.630-0.907、P〈0.01）, the neutrophile gyanulocyte count（OR=0.773、95%CI：0.644-0.926、P〈0.01） were risk factors ofrecurrent acute cerebral infarction. Conclusions：These results suggest that the rise of the count of leukocytrs and neutrophile cells have associations with attack of recurrent acute cerebral infarction,and are risk factors of recurrent acute cerebral infarction.