早期合用米非司酮与米索前列醇行药物流产的效果观察

Mifepristone combined with misoprostol for early medical abortion

目的研究早期合用米非司酮及米索前列醇行药物流产的效果。方法纳入本院84例早期药物流产孕妇为研究对象，遵循随机数字法平均分为对照组与研究组，对照组米非司酮治疗，研究组米非司酮联合米索前列醇治疗，比较两组宫缩时间、出血时间、清官2h平均出血量、流产成功率以及不良反应。结果研究组缩宫时间、出血时间明显短于对照组f（1．63±0．54）d比（2．68±0．67）d、（12．05±6．48）d比（16．37±5．59）d]，且清宫2h平均出血量明显少于对照组[（32．15±9．15）ml比（38．96±12．53）m1]（P〈0．05）；研究组流产成功率高于对照组（64．29％比42．86％，P〈0．05）；两组不良反应发生率差异无统计学意义（P〉0．05）。结论早期药物流产过程中合用米非司酮以及米索前列醇，可有效缩短缩宫时间、出血时间，减少清官后出血量，提升流产成功率，同时不良反应少。

Objective To study the effect of mifepristone combined with misoprostol for early medical abortion. Methods A total of 84 pregnant women who accepted early medical abortion at our hospital were taken as the clinical objects and were randomly divided into a control group （42 cases） and a study group （42 cases）. Both groups were given mifepristone; besides, the study group was given misoprostol. The contraction time, bleeding time, average bleeding volume 2 h after uterine curettage, successful rate of abortion, and adverse reactions in the two groups were compared. Results The contraction and bleeding times were （ 1.63±0.54 ） d and（ 12.05±6.48 ） d in the study group, which were obviously shorter than those in the control group [（ 2.68±0.67 ） d and （ 16.37±5.59 ） d] （ both P 〈 0.05 ）. The average bleeding volume 2 h after uterine curettage was （ 32.15±9.15 ） ml in the study group, which was obviously lower than that in the control group [ （ 38.96±12.53 ） ml] （ P 〈 0.05 ）. The successful rate of abortion was 64.29% in the study group, which was obviously higher than that in the control group （42.86%）（ P 〈 0.05 ）. There were no statisitcal differences in adverse reactions between these two groups（ P 〉 0.05 ） . Conclusion The combination of mifepristone and misoprostol for early medical abortion has fewer adverse reactions, can effectively shorten the contraction and bleeding times, reduce the bleeding volume after uterine curettage, and increase the successful rate of abortion.