摘要
目的研究基因儿茶酚胺氧位甲基转移酶(COMT)472G>A(rs4680)多态性和氧化还原酶1(NQO1)609C>T(rs1800566)多态性与山东汉族人群子痫前期发病的相关性。方法应用实时荧光定量PCR技术,检测并比较山东汉族800例正常孕妇(对照组)和600例子痫前期孕妇(子痫前期组)COMT472G>A和NQO1609C>T位点基因型差异。结果两组COMT 472G>A位点、NQO1 609C>T位点的基因型和等位基因分布差异均无统计学意义(P>0.05)。结论 COMT 472G>A和NQO1 609C>T两位点多态性与山东汉族人群子痫前期的发病没有相关性。
Objective To investigate the association of COMT 472G〉A （rs4680） and NQ01 609C〉T （rs1800566） polymorphisms with genetic susceptibility of preeclampsia （PE） in Han Chinese population in Shandong, China. Methods Quantitative real-time PCR was used to analyze and compare the genotypes of COMT 472G〉A and NQO1 609C〉T between 800 normal pregnant women （control group） and 600 pregnant women with PE （PE group）, all selected from the Han Chinese popula tion in Shandong Results There were no significant differences between the two groups in genotype and allele distributions of COMT 472G〉A and NQ01 609C〉T （P〉0.05）. Conclusion COMT 472G〉A and NQ01 6O9C〉T polymorphisms are not associated with the development of PE in Han women in Shandong.
出处
《青岛大学医学院学报》
CAS
2017年第4期420-423,共4页
Acta Academiae Medicinae Qingdao Universitatis
