腮腺嗜酸细胞型黏液表皮样癌1例临床病理观察并文献复习

ONCOCYTIC MUCOEPIDERMOID CARCINOMA OF THE PAROTID GLAND:CLINICOPATHOLOGICAL STUDY OF A CASE AND LITERATURE REVIEW

目的探讨腮腺嗜酸细胞型黏液表皮样癌(OMEC)的临床病理学特点、诊断及鉴别诊断,提高对OMEC的认识。方法总结1例腮腺OMEC的组织病理学及免疫组织化学特点,并复习相关文献。结果光镜下观察,肿瘤细胞主要由嗜酸性细胞及少许含黏液细胞构成,肿瘤排列成腺样、筛状及实性巢状结构。免疫表型:肿瘤细胞CK、CK7、CK14、EMA、p63及MUC5AC均呈阳性,而CK20、S-100、SMA及Vimentin均呈阴性。结论OMEC非常罕见,结合临床病理学特点及免疫组化染色有助于其诊断和鉴别诊断。

Objective To investigate the clinicopathological features,diagnosis,and differential diagnosis of oncocytic mucoepidermoid carcinoma（OMEC）of the parotid gland,and to raise the awareness of this disease. Methods The histopathological features and immunohistochemical features of one patient with OMEC of the parotid gland were summarized and related literature was reviewed. Results Microscopic observation showed that tumor cells mainly consisted of eosinophils and mucous cells and were arranged in an adenoid,cribriform,or nest-like shape.As for immunophenotype,tumor cells had positive CK,CK7,CK14,EMA,p63,and MUC5 AC and negative CK20,S-100,SMA,and Vimentin. Conclusion OMEC is an extremely rare type of mucoepidermoid carcinoma,and a combination of clinicopathological features and immunohistochemical staining may help with its diagnosis and differential diagnosis.