洛阳市美沙酮门诊海洛因依赖者HIV、HCV和梅毒感染状况分析

Investigation on infection status of HIV,HCV and syphilis among heroin dependence patients in methadone maintenance clinics of luoyang city

目的调查洛阳市美沙酮维持治疗门诊海洛因依赖者HIV、HCV和梅毒感染情况,为采取针对性干预措施提供依据。方法对2009年11月—2015年10月516例参加美沙酮维持治疗的海洛因依赖者采集静脉血,用酶联免疫吸附试验(ELISA)进行HIV、HCV及梅毒抗体血清学检测,同时进行问卷调查。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果 516例患者中HIV、HCV和梅毒的感染率分别是0.19%、9.50%、2.13%,女性HCV阳性率为15.83%,显著高于男性的7.58%,差异有统计学意义(P<0.05)。静脉吸毒者HCV阳性率为44.83%,高于非静脉吸毒者的7.39%,差异有统计学意义(P<0.05)。不同年龄段HCV阳性率比较差异有统计学意义(P<0.05)。结论洛阳市美沙酮门诊患者HCV和梅毒阳性率较高,应积极开展宣传教育和行为干预,控制HCV和梅毒的传播。

Objective To investigate the infection status of HIV, HCV and Syphilis among heroin dependence patients in methadone maintenance treatment（MMT） clinics of Luoyang City, to provide evidence for the formulation of preventive measures. Method The blood samples of 516 heroin dependence patients who treated with MMT from November 2009 to October 2015 were collected to test the antibodies of HIV, HCV and Syphilis by ELISA, the questionnaire was investigated at the same time. Measurement data were processed with t test,count data with chi-square test, P〈0.05 was considered statistically significant. Result The infection rates of HIV, HCV and Syphilis were 0.19%, 9.50% and 2.13% in 516 patients. The HCV infection rate in females（15.83%） or in intravenous injection drug users（44.83%） were significantly higher than in males（7.58%） or in non-intravenous injection drug users（7.39%）,which showed significant difference（all P〈0.05）. The HCV infection rate among different age groups showed significant difference（P〈0.05）.Conclusion The infection rates of HCV and Syphilis among patients in MMT clinics of Luoyang City were relatively high. It is necessary to enhance the healthy education and psycho-behavioral intervention in order to control the spread and prevalence of HCV and Syphilis.