372例奥硝唑氯化钠注射液不良反应分析

Analysis of 372 Cases of Adverse Drug Reactions Induced by Ornidazole Sodium Chloride Injection

目的了解奥硝唑氯化钠注射液的药品不良反应(ADR)一般规律,为减少不良反应发生率及临床安全用药提供参考。方法对我院2014年1月-2016年12月有关奥硝唑氯化钠注射液的372例不良反应报告从患者基本情况、用药情况、临床表现、不良反应发生时间、用药情况等方面进行统计分析。结果 372例ADR中女性多于男性,年龄主要集中在21~80岁之间。发生时间多为用药时,累及系统-器官主要为消化系统、神经系统等。有11例危及生命的严重不良反应,261例存在合并用药情况。结论奥硝唑氯化钠静脉滴注时应密切观察患者用药期间出现的不良反应,应科学安排输液顺序,避免潜在危险。

Objective To investigate the features of adverse drug reaction（ADR） induced by ornidazole sodium chloride injection, so as to provide advice for reducing adverse reaction rate and to promote the safe drug use in clinic.Me thods The ADR cases induced by ornidazole sodium chloride injection were searched between January 2014 and December 2016 in our hospital. Patients＇ basic characteristics, medication situation,clinical manifestation, clinical feature, ADR time and drug use were statistically analyzed. Re s ults The female cases were more than the males. Patients＇ age was from 21 to 80 years old. The ADRs mostly occurred in the process of medication. Main manifestations were digestive reactions, nervous reaction, et al. There were 11 serious ADR cases, 261 cases had the combination of drug use. Conclus ion The patients treated with ornidazole sodium chloride injection should be closely monitored.The infusion should be scientifically arranged the sequence when multi-drugs are used, so as to avoid potential risks.