女性Wolffian附件肿瘤临床病理分析并文献复习

Clinicopathological characteristic of female Wolffian adnexal tumor and literature review

对1例右输卵管系膜区Wolffian附件肿瘤(Wolffian adnexal tumor,WAT)进行HE、免疫组织化学及特殊染色检测,分析其病理特征,并复习相关文献。该病例肿瘤为体检中发现,无其他临床症状。镜下肿瘤由上皮样、椭圆形至梭形细胞组成,形成实质区、紧密排列的中空小管或网状结构。肿瘤细胞无异型性,核分裂象少见。免疫组织化学示CKpan,CK18,CR阳性,Vimentin,SMA局灶阳性,ER,PR,Inhibin,CD10,CK7,Desmin,HBME-1均阴性,Ki-67少数细胞散在阳性。WAT是一种罕见的具有低度恶性潜能的肿瘤,需与一系列其他妇科肿瘤相鉴别,并应对病人进行长期随访。

One case of Wolffian adnexal tumor was treated with HE, immunohistochemistry and special staining. The pathological features were analyzed and the related literatures were reviewed. The tumor was found in the physical examination with no other clinical symptoms. Microscopically, the tumor is composed of epithelioid cell, and oval to spindle cells, forming a parenchyma, closely spaced hollow tubules or reticular structures. Tumor cells had no atypia, and mitotic was rare. CKpan, CK18, CR were positive, Vimentin and SMA were partial positive, ER, PR, Inhibin, CD10, CK7, Desmin and HBME-1 were negative, and Ki-67 was sporadic positive. Wolffian adnexal tumor is a rare tumor with low malignant potential, and should be differential diagnosed with other gynecological tumors and closely followed-up long-term.