白细胞介素27在自身免疫性疾病中的功能调控

Functional Regulation of Interleukin-27 in Autoimmune Diseases

白细胞介素(IL)27是近年来发现的IL-6/IL-12家族因子的新成员。IL-27与其受体结合后能通过Janus激酶/信号转导及转录激活因子和p38丝裂原活化蛋白激酶等信号通路发挥免疫调控功能。辅助性T细胞(Th细胞)是IL-27调控的主要对象。IL-27促进Th1细胞增殖,但抑制Th2、Th17细胞和调节性T细胞分化,其特殊的差异性调控使IL-27在不同疾病环境中具有促炎或抑炎的双向调节功能。虽然IL-27参与临床常见自身免疫性疾病(类风湿关节炎、多发性硬化和炎症性肠病)的炎症反应,但机制尚未完全明确。因此,阐明IL-27的免疫调控作用不仅有助于认识自身免疫性疾病的病理生理过程,还为IL-27相关的临床治疗与药物开发提供了新思路。

Interleukin （IL） 27 is a new member of the IL-6/IL-12 family cytokines discovered in recent years. IL-27 can regulate immune responses through Janus kinase/signal transduction and activators of transcription and p38 mitogen- activated protein kinase pathway after binding to IL-27 receptor. Helper T （Th） cells are main targets in the regulation of IL-27. IL-27 promotes the proliferation of Thl cells, but inhibits the differentiation of Th2, Thl7 and regulatory T cells, and the special differential regulation results in both pro- and anti- inflammatory activities of IL-27 in different disease settings. Although IL-27 is involved in the inflammatory response of common clinical autoimmune diseases, such as rheumatoid arthri- tis, muhiple sclerosis and inflammatory bowel disease, the potential mechanisms of IL-27 in these diseases remain unclear. Therefore, the illumination of the role of IL-27 in autoimmune diseases not only contributes to understanding the pathophysi- ology of these diseases, but also provides new ideas for IL-27 related clinical treatment and new drug development.