新生儿缺氧缺血性脑病与白细胞介素关系的研究进展

Research Progress of Relationship between Hypoxic Ischemic Encephalopathy and Interleukin in Neonates

新生儿缺氧缺血性脑病(HIE)是指围生期新生儿因缺氧引起的脑部疾病,患儿通常因缺氧、缺血原因导致其多个器官的损伤或神经系统的功能障碍。目前HIE的发病机制还不是很清楚,所以对HIE疾病的研究成为当前围生医学专家研究的热点。患儿免疫系统的改变在HIE发病中的作用举足轻重,尤其是白细胞介素在HIE发病机制中发挥着重要作用,故深入开展新生儿HIE的免疫机制研究,做到早期诊断及早期干预,预防HIE并发症有重要的意义。

Hypoxic ischemic encephalopathy （HIE） refers to brain lesions caused by hypoxia in perinatal neonates, usu- ally combined with damage or dysfunction of other organs. The pathogenesis of HIE is very complex,which is still unclear, and it is one of the important subjects of perinatal medicine research. In recent years ,the role of the immune system in the pathogenesis of HIE has attracted more and more attention, especially interleukin, which plays an important role in the path- ogenesis of HIE. Therefore, further study on the immune mechanism of neonatal HIE, to realize early diagnosis and early intervention is of great significance for preventing HIE complications.