普瑞巴林在全膝关节置换术后镇痛的有效性及安全性

Efficacy and safety of oral pregabalin for analgesia after total knee arthroplasty

加速康复外科(enhanced recovery after surgery,ERAS)理念越来越受关节外科医师重视,通过各种围术期措施减少手术应激,降低疼痛与并发症的发生率,加快功能康复,提高患者满意度。其中优化疼痛管理是全膝关节置换术(TKA)加速康复的基石。近年来,研究发现普瑞巴林通过降低中枢和外周痛觉敏化,可以有效缓解TKA术后疼痛,减少阿片类药物的使用量,加速患者康复。因此,应用普瑞巴林可能是加速康复TKA围手术期多模式镇痛中的一种有效措施。

The aim of enhanced recovery after surgery （ERAS） is to reduce surgical stress and incidences of pain and complications, enhance functional rehabilitation, and improve patients＇ satisfaction by using approved efficient methods in perioperative period. Better pain control is the basis of ERAS. Recent evidence suggests that α2-δ subunit calcium channel ligands, like pregabalin, may aid in providing effective postsurgical analgesia. They mitigate central sensitization by calming down hyperexcited dorsal horn neurons. Therefore, application of pregabalin may be an effective method for reducing early postoperative pain and narcotic consumption.