疏血通注射液对急性脑梗死患者炎症因子和血小板活化因子的影响

Effects of Shuxuetong Injection on serum inflammatory factors and platelet activating factors in patients with acute cerebral infarction

目的探讨疏血通注射液对急性脑梗死(ACI)患者炎症因子和血小板活化因子的影响。方法将2015年4月~2016年12月北京市石景山医院收治的60例ACI患者随机分为常规治疗组与研究组,各30例。常规治疗组患者给予常规西药治疗,研究组在此基础上给予疏血通注射液治疗。对比两组临床疗效,评价美国国立卫生研究院神经功能缺损程度评分量表(NIHSS)评分和Barthel指数(BI),检测治疗前后血清炎症因子和血小板活化因子。结果研究组总有效率为93.33%,明显高于常规治疗组的73.33%,差异有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分均明显降低,BI均明显增大,且研究组NIHSS评分、BI变化优于常规治疗组,差异均有统计学意义(均P<0.05)。治疗后,两组血清炎症因子和血小板活化因子均明显降低,且研究组血清炎症因子和血小板活化因子水平均明显低于常规治疗组,差异均有统计学意义(均P<0.05)。结论疏血通注射液治疗ACI患者临床效果显著,能够有效改善患者神经功能,提高日常生活能力,降低血清炎症因子及血小板活化因子,值得在临床上推广应用。

Objective To study the effects of Shuxuetong Injection on serum inflammatory factors and platelet activating factors in patients with acute cerebral infarction （ACI）. Methods Sixty patients with ACI admitted to Beijing Shijingshan Hospital from April 2015 to December 2016 were randomly divided into the conventional treatment group and the study group, with 30 cases in each group. The conventional treatment group was treated with the conventional western medicine, on basis of which, the study group was treated with Shuxuetong Injection. The clinical effects of the two groups were compared. The national institute of health neurological impairment scale （NIHSS） and Barthel index （BI） were evaluated. The serum inflammatory factors and platelet activating factors were examined before and after treatment. Results The total efficacy rate of the study group was 93.33%, which was significantly higher than 73.33% of the conventional treatment group （P 〈 0.05）. After treatment, the NIHSS scores of the two groups were significantly reduced, BI scores were significantly increased, and the improvement of NIHSS, BI in the study group was significantly better than that of conventional treatment group, the differences were all statistically significant （all P 〈 0.05）. After treatment, the levels of serum inflammatory factors and platelet activating factors in the two groups were all significantly decreased, and the levels of serum inflammatory factors and platelet activating factors in the study group were significantly lower than those in the conventional treatment group, the differences were all statistically significant （all P 〈 0.05）. Conclusion Shuxuetong In- jection for patients with acute cerebral infarction has a good efficacy, which can improve the nervous function and daily life, reduce the serum inflammatory factors and platelet activating factors, and it is worthy of clinical promotion and application.