我院259例患者围术期质子泵抑制剂的应用情况分析

Analysis on application of proton-pump inhibitor of 259 patients during the perioperative period in our hospital

目的了解南京医科大学第二附属医院(以下简称"我院")围术期质子泵抑制剂的使用情况,对存在的不合理现象进行分析,为围术期质子泵抑制剂的合理使用提供参考。方法查阅我院2016年7月~2017年1月出院患者病历,选择其中围术期使用质子泵抑制剂的患者259例,统计并分析其质子泵抑制剂使用情况。结果 259例患者质子泵抑制剂均为静脉给药,其中165例(63.7%)无应激性溃疡风险因素,属无指征用药;给药频次不合理137例(52.9%);平均用药疗程为4.59 d。259例患者中质子泵抑制剂费用占药品总费用的5.63%,占住院总费用的1.98%,其中,无指征使用质子泵抑制剂的费用占质子泵抑制剂总费用的47.7%。结论我院围术期无适应证使用质子泵抑制剂的比例较高,且存在给药频次和用药疗程不合理的情况,需加强管理,规范质子泵抑制剂的使用。

Objective To investigate the application of proton pump inhibitors （PPIs） in patients during the perioperative period in the Second Affiliated Hospital of Nanjing Medical University （＂our hospital＂ for short）, analyze the irra- tional phenomenon, in order to provide reference for rational drug use. Methods 259 patients during the perioperative period used PPIs were chosen from July 2016 to January 2017 in several departments of our hospital, and their PPIs application situation were analyzed. Results All the PPIs were given by intravenous administration. 165 （63.7%） cases had no risk of stress ulcer. 137 cases （52.9%） had irrational of drug frequency. The average duration was 4.59 d. The consumption sum of PPIs accounted for 5.63% of the total drug consumption sum and 1.98% of the total hopspitalization cost, among which, the consumption sum of PPIs in patients with no risk factors for stress ulcer accounted for 47.7% of the total consumption sum for PPIs. Conclusion There is high rate of irrational perioperative use of PPIs in our hospital, including irrational of drug frequency and duration. More powerful management should be given, in order to regulate the use of PPIs.