奥曲肽不同给药方法治疗急性胰腺炎的效果对比

Comparison of effects of different methods of administration of Octreotide in the treatment of acute pancreatitis

目的比较奥曲肽不同给药方法治疗急性胰腺炎的效果。方法选取2015年4月~2017年4月我院收治的80例急性胰腺炎患者,依据给药方法的不同分为常规静脉滴注组(静滴组,n=40)和微量输液泵持续泵注组(泵注组,n=40)两组,对两组患者的血清白介素-1(IL-1)、白介素-8(IL-8)、肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)水平、临床疗效、呕心呕吐缓解时间、腹痛缓解时间、淀粉酶恢复正常时间、住院时间、不良反应发生情况进行统计分析。结果泵注组患者的血清IL-1、IL-8、TNF-α、CRP水平均显著低于静滴组(P<0.05),治疗的总有效率[95.0%(38/40)]显著高于静滴组[82.5%(33/40)](P<0.05),呕心呕吐缓解时间、腹痛缓解时间、淀粉酶恢复正常时间、住院时间均显著短于静滴组(P<0.05),不良反应发生率[10.0%(4/40)]显著低于静滴组[17.5%(7/40)],差异均有统计学意义(P<0.05)。结论奥曲肽微量输液泵持续泵注较常规静脉滴注给药治疗急性胰腺炎的效果好。

Objective To compare the effects of different methods of administration of Octreotide in the treatment of acute pancreatitis.nethods 80 cases of patients with acute pancreatitis in our hospital from April 2015 to April 2017 were selected,these patients were divided into routine intravenous infusion group （intravenous group,n=40） and micro infusion pump continuous infusion group （injection pump group,n=40） according to the methods of administration,the serum IL-1, IL-8,TNF-α,CRP levels,clinical efficacy,nausea and vomiting remission time,abdominal pain relief time,amylase recovery time,hospitalization time,incidences of adverse reactions of the two groups were statistically analyzed.Results The serum IL-1,IL-8,TNF-α,CRP levels of the injection pump group were significantly lower than the intravenous group （P〈0.05）, the total treatment efficiency [95.0% （38/40）] was significantly higher than the intravenous group [82.5% （33/40）] （P〈0.05）, the nausea and vomiting remission time,abdominal pain relief time,amylase recovery time,hospitalization time were significantly shorter （P〈0.05）,the incidence of adverse reactions [10.0% （4/40）] was significantly lower than the intravenous group [17.5% （7/40）],the difference was statistically significont（P〈0.05）.Conclusion The effect of micro infusion pump continuous infusion is better than routine intravenous infusion in the treatment of acute pancreatitis.