米非司酮联合米索前列醇用于瘢痕子宫中期妊娠引产临床效果观察

Observation the clinical effect of Mifepristone combined with Misoprostol in induction of labor in the middle trimester of scar uterus

目的探索米非司酮联合米索前列醇用于瘢痕子宫中期妊娠引产临床效果。方法选取2015年5月~2016年5月我院收治的100例瘢痕子宫中期妊娠引产患者作为研究对象,将其抽签化分为两组,,每组各50例。对照组采用经腹壁行羊膜腔注射治疗,观察组采用米非司酮联合米索前列醇治疗。比较两组患者的并发症发生率、胎盘残留率、出血量、引产成功率、用药至宫缩发动时间、宫缩至胎儿胎盘娩出时间、用药至胎儿胎盘娩出时间。结果观察组患者的用药至宫缩发动时间[(27.69±3.52)h]、宫缩至胎儿胎盘娩出时间[(8.52±1.44)h]、用药至胎儿胎盘娩出时间[(34.53±3.95)h]短于对照组[(35.86±5.86)h,(11.32±2.56)h,(48.91±5.22)h],差异有统计学意义(P<0.05)。观察组患者的胎盘残留率(4.00%)低于对照组(30.00%),出血量[(142.74±25.98)ml]少于对照组[(159.86±36.85)ml],引产成功率(98.00%)高于对照组(76.00%),差异均有统计学意义(P<0.05)。观察组患者的并发症发生率(2.00%)低于对照组(26.00%),差异有统计学意义(P<0.05)。结论对瘢痕子宫中期妊娠引产患者实施米非司酮联合米索前列醇治疗,能够提高引产成功率,降低治疗风险性。

Objective To investigate the clinical effect of Mifepristone combined with Misoprostol in induction of labor in the middle trimester of scar uterus.Methods 100 induction of labor in the second trimester of scar uterus patients from May 2015 to May 2016 treated in our hospital were selected as objects.Patients were divided into two groups according to lottery method,and each group was 50 cases.The control group and observation group were respectively given treatment of abdominal wall with amniotic Membrane Injection and Mifepristone combined with Misoprostol.Two groups of patients with complications,placental residual rate,bleeding volume,successful rate of induced labor,duration of medication to contractions start time,the contractions to the fetal placental delivery time,delivery time to the fetal placenta were compared.Results Observation group of patients with duration of medication to contractions start time [（27.69±3.52） h],the contractions to the fetal placental delivery time [（8.52±1.44） hi,delivery time to the fetal placenta [（34.53±3.95） h] were shorter than those in the control group [（35.86±5.86） h,（11.32±2.56） h,（48.91±5.22）h],the differences were statistically significant （P〈0.05）.Plaeental retention rate of the patients in observation group （4.00%） was lower than the control group （30.00%）,the bleeding volume of the patients in observation group [（142.74±25.98） ml] was less than the control group [（159.86±36.85） ml],the success rate of induced labor （98.00%） was higher than the control group （76.00%）,the differences were statistical significance （P〈0.05）.The incidence of complications in the observation group （2.00%） was lower than the control group （26.00%）,and the difference was statistically significant （P〈0.05）.Conclusion Mifepristone combined with Misoprostol in the treatment of induced abortion in the middle trimester of scar uterus can improve the success rate of induced labor and reduce the risk of treatment.