纤蛋白3诊断恶性胸膜间皮瘤准确性的Meta分析

Accuracy of fibulin-3 in the diagnosis of malignant pleural mesothelioma：a Meta-analysis

目的 探讨血液及胸腔积液中纤蛋白3（fibulin-3）在恶性胸膜间皮瘤（MPM）早期诊断中的作用.方法 通过计算机检索2017年2月以前发表的fibulin-3诊断MPM的中英文文献,根据纳入和排除标准进行筛选,提取文献数据.建立分析模型,并探索异质性的来源.结果 按照选择标准最终有9篇文献26项独立研究纳入Meta分析,采用随机效应模型发现试验组（MPM组）患者血液及胸腔积液的fibulin-3水平高于对照组（非MPM组）.采用地区亚组分析发现,欧美人群中试验组的fibulin-3水平高于对照组.结论 fibulin-3诊断MPM具有较高程度的敏感性和特异性,可作为MPM临床早期诊断的辅助方法 .

Objective To study the role of fibulin-3 in blood and pleural effusion in the early diagnosis of malignant pleural mesothelioma （MPM）. Methods Chinese and English literatures about fibulin-3 in the diagnosis of MPM before February 1, 2017 were searched through the computer. After the screening according to the criteria, literature data were extracted to build the analysis model and explore the origin of the heterogeneity. Results According to the selection criteria, 9 literatures including 26 independent study were taken into Meta analysis eventually. The level of fibulin-3 in blood and pleural effusion in the experimental group was higher than that in the control group by using the random effect model. The region subgroup analysis showed that the fibulin-3 level in the experimental group was higher than that in the control group among European and American people. Conclusion Fibulin-3 in the diagnosis of MPM has a higher sensitivity and heterogeneity, which could be served as an auxiliary method in early diagnosis of MPM.