miRNA-29b在肿瘤中的研究进展

Progress of microRNA-29b in tumors

微RNA（miRNA）是真核生物体内在转录后水平调控基因表达的一类高度保守的miRNA.大量研究表明,miRNA通过调节许多重要癌基因或抑癌基因的表达来调控肿瘤的恶性生物学表型,miRNA异常表达已成为肿瘤的重要特征之一.miRNA-29b（miR-29b）在各类肿瘤组织中普遍呈低表达,其表达上调将抑制某些靶基因的表达从而在肿瘤的发生、发展过程中发挥着极为重要的调控作用,有望成为肿瘤早期诊断及预后评估的生物学标志物,是潜在肿瘤药物开发及新型治疗的新靶点.

MicroRNA （miRNA） is a kind of highly conserved microRNA molecules that regulate gene expression after transcriptional levels in eukaryotes. Numerous evidences indicate that miRNA can regulate malignant phenotypes of neoplasms by repressing the expressions of critical oncogenes or tumor suppressor genes, and abnormal expression of miRNA becomes one of the most important features of cancer. The expression of miR-29b was low in multiple types of tumors and its up-regulated expression will depress the expression of some target genes, which plays a crucial role in the occurrence and development of various neoplasms and is expected to serve as a biomarker for early diagnosis and prognosis assessment becoming a novel target of drug development and new treatment.