哈密地区维吾尔族与汉族妇女乳腺癌组织中CerbB-2、Ki-67、p53的表达及临床意义

Expressions of CerbB-2,Ki-67,and p53 in cancer tissues of Uygur and Han patients with breast cancer in Hami prefecture and the clinical significance

目的探究哈密地区维吾尔族与汉族患乳腺癌女性的癌组织中CerbB-2、Ki-67、p53的意义和表达的状况。方法选取哈密地区中心医院2011年1月~2015年10月的汉族乳腺癌患者100例,维吾尔族乳腺癌患者80例入选为研究对象。以免疫组织化学SP法联合检测哈密地区维吾尔族与汉族妇女乳腺癌组织中CerbB-2、Ki-67、p53的表达,探讨不同民族间其表达差异以及年龄、肿块大小、淋巴结转移情况与其表达的关系。评价其可否作为判断乳腺癌预后的指标。结果 CerbB-2在维吾尔族妇女乳腺癌组织中的表达阳性率明显高于汉族妇女,差异有统计学意义(χ~2=5.040,P<0.05)。Ki-67、p53在维吾尔族与汉族妇女乳腺癌组织中的表达阳性率差异无统计学意义(χ~2=1.067、1.001,均P>0.05)。维吾尔族与汉族妇女乳腺癌组织中CerbB-2、Ki-67、p53的表达与淋巴结转移状况、病理类型、肿块大小均呈正相关(均P<0.05)。结论 CerbB-2在维吾尔族与汉族患乳腺癌女性的癌组织中的表达具备民族的区别,Ki-67及p53不具备民族的区别。CerbB-2、Ki-67、p53能够作为判断维吾尔族与汉族妇女乳腺癌预后的指标。

Objective To explore the significance and expressions of CerbB-2,Ki-67,and p53 in cancer tissues of Uygur and Han patients with breast cancer in Hami prefecture. Methods One hundred Han patients with breast cancer and eighty Uygur patients with breast cancer were selected from the hospital from January 2011 to October 2015. Immunohistochemical SP method was used to detect the expressions of CerbB-2,Ki-67,and p53 in cancer tissues of Uygur and Han patients with breast cancer in Hami prefecture. The expressions of CerbB-2,Ki-67,and p53 in cancer tissues of Uygur and Han patients with breast cancer were compared,their relationships with age,tumor size,and lymph node metastasis were analyzed,the value of CerbB-2,Ki-67,and p53 used to predict prognosis of breast cancer was evaluated. Results The positive expression rate of CerbB-2 in breast cancer tissue of Uygur women was statistically significantly higher than that of Han women（ χ~2= 5. 040,P 0. 05）. There was no statistically significant difference in the positive expression rates of Ki-67 and P53 in breast cancer tissue between Uygur women and Han women（ χ2= 1. 067,P0. 05; χ~2= 1. 001,P0. 05）. In breast cancer tissues of Uygur and Han women,the expressions of CerbB-2,Ki-67,and p53 were positively correlated with lymph node metastasis,pathological types,and tumor size（ P0. 05）. Conclusion The expressions of CerbB-2 in breast cancer tissue are different between Uygur women and Han women,while the expressions of Ki-67 and P53 are not different. CerbB-2,Ki-67,and P53 can be used to predict prognosis of breast cancer in Uygur and Han women.