摘要
目的对比两种不同药物方案治疗女性贫血的临床疗效和不良反应。方法回顾性分析2013年6月-2016年10月杭州市第一人民医院门诊收治的191例女性贫血患者,根据治疗药物分成琥珀酸亚铁组和多糖铁复合物组。不同方法治疗后,比较两组的临床疗效血清血红蛋白(Hb)、红细胞(RBC)变化,观察不良反应发生情况。结果琥珀酸亚铁组和多糖铁复合物组的临床总有效率分别为92.78%和82.98%,差异有统计学意义(P<0.05);治疗后2周、4周,琥珀酸亚铁组血清Hb、RBC明显高于多糖铁复合物组(P<0.05);琥珀酸亚铁组的胃肠道不良反应发生率明显高于多糖铁复合物组(P<0.05)。结论琥珀酸亚铁提高了女性贫血临床治疗的总有效率,促进了血清Hb、RBC的恢复,但对胃肠道有一定的刺激,临床中应根据患者特点选择治疗方案。
Objective To compare the clinical effects and adverse reactions of two different drug regimens in treatment of female anemia. Methods A total of 191 female patients with anemia treated in Outpatient Department of the hospital from June 2013 to October 2016 were analyzed retrospectively,then the patients were divided into ferrous succinate group and polysaccharide iron complex group. After treatment,the changes of serum hemoglobin( Hb) and erythrocyte( RBC) levels were compared between the two groups. The adverse reactions were observed. Results The total clinical effective rates in ferrous succinate group and polysaccharide iron complex group were 92. 78% and82. 98%,respectively,there was statistically significant difference between the two groups( P0. 05). At 2 and 4 weeks after treatment,the levels of serum Hb and RBC in ferrous succinate group were statistically significantly higher than those in polysaccharide iron complex group( P0. 05). The incidence rate of gastrointestinal tract adverse reactions in ferrous succinate group was statistically significantly higher than that in polysaccharide iron complex group( P 0. 05). Conclusion Ferrous succinate improves the total effective rate of clinical treatment and promotes the recovery of serum Hb and RBC,but it has a certain stimulation on gastrointestinal tract,the therapeutic regimens should be selected according to the characteristics of patients.
出处
《中国妇幼保健》
CAS
2017年第21期5218-5220,共3页
Maternal and Child Health Care of China
基金
杭州市科技发展计划医疗卫生及重点专科专病科研项目(20140733Q12)
关键词
琥珀酸亚铁
多糖铁复合物
贫血
Ferrous succinate
Polysaccharide iron complex
Anemia