茵栀黄联合更昔洛韦治疗早产儿巨细胞病毒性肝炎的疗效及对患儿IL-8、INF-γ、D-二聚体和vWF的影响

Curative effect of Yinzhihuang combined with ganciclovir in treatment of cytomegalovirus hepatitis of premature infants and the influence on IL-8,INF-γ,D-dimer,and vWF

目的探讨茵栀黄联合更昔洛韦治疗早产儿巨细胞病毒性(CMV)肝炎及对患儿血清白细胞介素-8(IL-8)、干扰素(INF-γ)、血浆D-二聚体(D-D)和血管性假血友病因子(v WF)的影响。方法选取该院2015年1月-2016年12月收治的100例CMV肝炎患儿临床资料进行回顾性分析,根据治疗方法分为联合组(50例)和对照组(50例);两组均给予常规保肝、退黄及更昔洛韦治疗,联合组在对照组治疗的基础上给予茵栀黄治疗,疗程2周。结果治疗前,两组患儿的血清AST、ALT、TBIL、DBIL、γ-GT、IL-8、INF-γ、D-D、v WF水平比较差异均无统计学意义(均P>0.05);治疗后,两组患儿的血清AST、ALT、TBIL、DBIL、γ-GT、IL-8、INF-γ、D-D、v WF水平较本组治疗前均显著降低(均P<0.05),且联合组患儿的下降水平较对照组显著(P<0.05);治疗后,联合组患儿痊愈率为74.00%、有效率为22.00%、无效率为4.00%,对照组分别为52.00%、38.00%、10.00%,两组比较差异均有统计学意义(均P<0.05)。结论茵栀黄联合更昔洛韦治疗早产儿CMV肝炎能进一步提升治疗效果,改善肝功能,减轻肝损害。

Objective To explore the curative effect of Yinzhihuang combined with ganciclovir in treatment of cytomegalovirus hepatitis of premature infants and the influence on interleukin-8（ IL-8）,interferon-γ（ INF-γ）,D-dimer,and von Willebrand factor（ v WF）.Methods The clinical data of 100 premature infants with cytomegalovirus hepatitis treated in the hospital from January 2015 to December2016 was analyzed retrospectively,all the premature infants were divided into combined group and control group,50 premature infants in each group. The premature infants in the two groups were treated by conventional liver protection,removing jaundice,and ganciclovir,the premature infants in combined group were also treated by Yinzhihuang treatment,the treatment was continued for 2 weeks. Results Before treatment,there was no statistically significant difference in the levels of serum aspartate aminotransferase（ AST）,alanine aminotransferase（ ALT）,total bilirubin（ TBIL）,direct bilirubin（ DBIL）,γ-glutamyltransferase（ γ-GT）,IL-8,INF-γ,D-dimer,and v WF between the two groups（ all P 0. 05）. After treatment,the levels of serum AST,ALT,TBIL,DBIL,γ-GT,IL-8,INF-γ,D-dimer,v WF decreased significantly（ all P0. 05）,especially in combined group（ P0. 05）. After treatment,the cure rate,effective rate,and ineffective rate in combined group were 74. 00%,22. 00%,and 4. 00%,respectively; the cure rate,effective rate,and ineffective rate in control group were 52. 00%,38. 00%,and 10. 00%,respectively; there were statistically significant differences between the two groups（ all P0. 05）.Conclusion Yinzhihuang combined with ganciclovir can further improve the curative effect and liver function,relieve liver injury in treatment of cytomegalovirus hepatitis of premature infants.