基于因子分析和Logistic回归分析的溃疡性结肠炎证候分类及量化标准研究

Study on Syndrome Classification and Quantitative Diagnosis Criteria of Ulcerative Colitis Based on Factor Analysis and Logistic Regression Analysis

目的:探讨因子分析和Logistic回归分析在溃疡性结肠炎中医证候研究中的应用,为溃疡性结肠炎证候分类及制定诊断标准提供一定的科学依据。方法:采用自拟《溃疡性结肠炎中医证候流行病学调查表》收集溃疡性结肠炎患者441例,并行因子分析和Logistic回归分析。结果:应用因子分析的方法,得出溃疡性结肠炎基本中医证候为脾胃气虚证、大肠湿热证、脾肾阳虚证、肝郁脾虚证、阴虚肠燥证、血瘀肠络证6类;运用多元Logistic回归分析,得出溃疡性结肠炎证候的症状量化指标。结论:因子分析和Logistic回归分析结合的多元统计方法可用于溃疡性结肠炎中医证候分类及量化诊断研究,为该病的证候诊断标准研究提供了一种新的方法。

Objective：To explore the application of factor analysis and logistic regression analysis in the study of traditional Chinese medicine（TCM） syndromes of ulcerative colitis,and to provide a scientific basis for the classification of ulcerative colitis syndrome and the development of diagnostic criteria. Methods：A self-made＂ulcerative colitis TCM syndrome epidemiology questionnaire＂ was applied,and 441 cases of ulcerative colitis were collected and analyzed by factor analysis and cluster analysis method. Results：Using the method of factor analysis,the basic TCM syndromes of ulcerative colitis determined were qi deficiency of spleen and stomach,damp heat in large intestine,yang deficiency in spleen and kidney,liver stagnation and spleen deficiency syndrome,yin deficiency and intestinal dryness,and blood stasis in intestinal collaterals. Multiple logistic regression analysis were applied to obtain the symptom qualification index for ulcerative colitis. Conclusion：Multivariate statistical methods of factor analysis and logistic regression analysis can be used for the classification and quantitative diagnosis of ulcerative colitis,and it can provide a new method to study the syndrome diagnosis standard of this disease.