尤瑞克林联合阿司匹林对急性脑梗死患者血清学指标及临床疗效的影响

Curative efficacy of urinary kallidinogenase combined with aspirin in treatment of acute cerebral infarction and its effects on serum markers

目的探讨尤瑞克林联合阿司匹林治疗急性脑梗死的作用机制。方法选取86例急性脑梗死患者,随机分为观察组(n=43)和对照组(n=43),在常规治疗基础上,观察组予尤瑞克林及阿司匹林治疗,对照组仅予阿司匹林,治疗后2周比较两组患者血液流变学、同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)、胱抑素(Cys)-C、白介素(IL)-6、神经功能缺损(NIHSS)及日常生活能力(ADL)等。结果观察组血清Hcy、hs-CRP、VEGF、Cys-C、IL-6、NIHSS、ADL均优于对照组(P<0.05);观察组临床疗效明显比对照组高[95.35%(41/43)vs 74.42%(32/43)](P<0.05)。结论在急性脑梗死患者中应用尤瑞克林联合阿司匹林效果显著,其内在机制可能和早期改善血清Hcy、hs-CRP、VEGF、Cys-C、IL-6的表达相关。

Objective To study the mechanism of urinary Kallidinogenase combined with aspirin in treat-ment of acute cerebral infarction. Methods Eighty-six patients with acute cerebral infarction were randomly divid-ed into the observation group(n=43)and the control group(n=43). The observation group was treated with uri-nary Kallidinogenase combined with aspirin,while the control group was treated only with aspirin. Two weeks afterthe treatment,variables of hemorheology,serum Hcy,hs-CRP,VEGF,IL-6,Cys-C,neurological deficit(NI-HSS)and daily living ability(ADL)were compared between the two groups. Results After treatment,the serumHcy,hs-CRP,VEGF,Cys-C,IL-6 levels,the NIHSS and ADL in the observation group were significantly betterimproved than those of the control group(P<0.05). The clinical efficacy in the observation group was significantlyhigher than that of the control group[95.35%(41/43)vs 74.42%(32/43)](P<0.05). Conclusion Urinary Kal-lidinogenase combined with aspirin is more effective in the treatment of acute cerebral infarction. The mechanismmay be related to the early improvements of serum Hcy,hs-CRP,VEGF,Cys-C and IL-6 expression.