包虫病的药物经济学评价研究

Pharmacoeconomic evaluation of albendazole and mebendazole in treatment of echinococcosis

目的比较阿苯达唑和甲苯咪唑治疗包虫病的经济效果。方法选择2014-2015年在新疆医科大学第一附属医院住院治疗的包虫病患者108例,随机分成阿苯达唑组和甲苯咪唑组,分别给予治疗。运用药物经济学的成本效果分析方法进行分析。结果阿苯达唑组治疗的有效率为57.9%,甲苯咪唑组治疗的有效率为51.0%;阿苯达唑组的成本-效果比(C/E)为14.6%,甲苯咪唑组的C/E为34.7%;阿苯达唑组的不良反应发生率为3.5%,甲苯咪唑组的不良反应发生率为5.9%。结论阿苯达唑组和甲苯咪唑组方案治疗包虫病,临床总有效率无明显差异,阿苯达唑治疗包虫病的经济学成本较好。

Objective To compare the economic effects of albendazole and mebendazole in the treatment of echinococcosis.Methods A total of 108 inpatients with echinococcosis from 2014 to 2015 were enrolled and they were randomly divided into albendazole group and mebendazole group,respectively.The cost effectiveness analysis method of pharmacoeconomics was used for analysis and evaluation.Results The effective rate in Albendazole treatment group was 57.9%,while which in mebendazole treatment group was 51%;the rate of cost-effectiveness(C/E)in albendazole group was 14.6%,while which in mebendazole group was 34.7%;the rate of adverse reactions in albendazole group was 3.5% and the rate of the adverse reaction in mebendazole group was 5.9%.Conclusion There was no significant difference between albendazole group and mebendazole group in the effective rate and the cure rate in the treatment of echinococcosis.The economic cost of albendazole in treatment for echinococcosis was better.