小牛血去蛋白提取物眼用凝胶与玻璃酸钠滴眼液在儿童干眼症治疗中的应用价值对比

Application value contrast between calf blood deproteinized extract ophthalmic gel and sodium hyaluronate eye drops in the treatment of dry eye syndrome in children

目的探讨在儿童干眼症治疗中分别应用小牛血去蛋白提取物眼用凝胶与玻璃酸钠滴眼液的临床价值。方法选取2014年1月~2016年12月我院收治的干眼症患儿140例为研究对象,以随机数字表法分为A组70例、B组70例,A组给予小牛血去蛋白提取物眼用凝胶治疗,B组给予玻璃酸钠滴眼液治疗,观察两组治疗效果、临床指标变化及不良反应发生情况。结果 A组治疗总有效率为92.86%,同B组的81.43%比较,显著较高,差异有统计学意义(P<0.05);治疗前两组患儿临床相关指标无显著差异(P>0.05),治疗后均有改善,A组治疗后症状积分明显较对照组低,泪膜破裂时间(BUT)、基础泪液分泌试验(SIt)显著较对照组长,差异有统计学意义(P<0.05);A组不良反应发生率为2.86%,同B组的5.71%比较,差异无统计学意义(P>0.05),两组均未出现严重不良反应。结论相比于玻璃酸钠滴眼液,小牛血去蛋白提取物眼用凝胶治疗儿童干眼症效果更为显著,可促进患儿症状改善,且安全性高,更值得推广。

Objective To investigate the clinical value of application of calf blood deproteinized extract ophthalmic gel and sodium hyaluronate eye drop in the treatment of dry eye in children. Methods A total of 140 children with dry eye syndrome admitted in our hospital from January 2014 to December 2016 were enrolled. And the patients were divided into group A（n=70） and group B（n=70）. The group A was treated with calf blood deproteinized extract ophthalmic gel.The group B was treated with sodium hyaluronate eye drops. And the curative effect, the changes of clinical indexes and adverse reactions of the two groups were observed. Results The total treatment effective rate was 92.86% in group A, which was significantly higher than that in group B（81.43%）, and the difference was significant（P0.05）. There was no significant difference in the clinical related indicators between the two groups before treatment（P0.05）. The clinical related indicators were all improved after treatment. The symptom score of group A was significantly lower than that of the control group after treatment, and the tear film breakup time（BUT） and basal tear secretion test（SIt） in the group A were significantly longer than those in the group B, and the differences were significant（P0.05）. The incidence of ad verse reactions in group A was 2.86%, which has no significant difference compared with 5.71% of group B（ P0.05）.There were no serious adverse reactions in the two groups. Conclusion The calf blood deproteinized extract ophthalmic gel is more effective than that of the sodium hyaluronate eye drops in the treatment of dry eye syndrome in children.The former can promote the improvement of symptoms in children and has high safety, which is more worthy of promotion.