肝细胞性肝癌手术治疗的疗效及影响因素的分析

Analysis of Survival Rate and Influence Factors of Surgical Treatment for Hepatocellular Carcinoma

目的对肝细胞性肝癌患者进行手术治疗,并分析影响其术后生存率的因素。方法选取肝细胞性肝癌患者100例,根据肿瘤大小、位置选择行肝叶、肝段、半肝和局部切除术,术后进行电话随访,分析术后生存率的影响因素。结果肿瘤大小、术前AFP、术后AFP、血管侵犯、辅助治疗、有无肝硬化,与患者术后生存率有相关性(P<0.05),与性别、年龄、乙肝抗原、手术方式无关(P>0.05);术前术后AFP变化、血管侵犯和肝硬化是影响肝细胞性肝癌患者术后生存率的独立因素(P<0.05)。结论肿瘤大小、血管侵犯、术前AFP、术后AFP、辅助治疗、肝硬化均与肝细胞性肝癌患者手术治疗后的生存率有关;术前术后AFP、血管侵犯、肝硬化是影响肝细胞性肝癌患者术后生存率的独立因素。

Objective To study the factors affecting the survival rate of hepatocellular carcinoma patients treated with surgical treatment.Methods 100 cases of patients with hepatocellular carcinoma ,according to tumor size and location to choose liver lobe,liver,and local resection,follow-up after surgery,from gender,age,hepatitis B antigen,tumor location,tumor number, preoperative AFP,AFP changes,surgical methods,Child classification,vascular invasion,adjuvant treatment,pathological typing, and cirrhosis to analyze the factors that affecting the survival rate.Results Tumor size ,preoperative and postoperative AFP ,vas-cular invasion,adjuvant therapy,with or without cirrhosis were correlated with postoperative survival rate （P〈0.05）,but were not correlated with gender,age,hepatitis B surface antigen,tumor size,mode of operation,pathological type（P〉0.05）;Preoperative and postoperative changes of AFP ,vascular invasion and liver cirrhosis were independent influencing factors of primary liver canc -er patients postoperative survival rate （P〈0.05）.Conclusion Tumor size,vascular invasion,preoperative AFP,postoperative AFP,adjuvant therapy ,and liver cirrhosis are related to the survival rate of patients with hepatocellular carcinoma after surgical treatment;AFP,vascular invasion and liver cirrhosis are independent factors affecting the survival rate of patients with hepatocellu -lar carcinoma after operation.