紫杉醇及蒽环类药物联合化疗治疗晚期乳腺癌的临床观察

Clinical Observation of Paclitaxel and Anthracycline-based Drugs Combined with Chemotherapy for Advanced Breast Cancer

目的分析紫杉醇及蒽环类药物联合化疗治疗晚期乳腺癌的临床疗效和安全性。方法以74例乳腺癌晚期患者为研究对象,将患者分为观察组和对照组,对照组患者采用CAF方案治疗,观察组患者采用紫杉醇联合蒽环类±CTX方案治疗,对比两组患者的缓解率、不良反应。结果观察组的有效率为83.78%,对照组为56.76%,差异有统计学意义(χ~2=1.583,P=0.017)。观察组出现神经毒性和肌肉关节疼痛几率高于对照组,差异有统计学意义(P<0.05);两组患者出现血细胞和血小板下降、恶心呕吐、贫血、脱发、肝功能异常和过敏反应的几率差异不显著(P>0.05)。结论紫杉醇联合蒽环类药物±CTX方案治疗晚期乳腺癌患者的疗效更高,但轻微不良反映较多的,治疗前及治疗期间应做并发症防治措施,预防和减轻并发症。

Objective To study the clinical efficacy and safety of paclitaxel and anthracycline-based drugs combined with chemotherapy for advanced breast cancer.Methods 74 breast cancer patients were divided into the observation group and the control group ,the control group were treated by CAF regimen ,the observation group were treated by paclitaxel plus anthracy-cline-based ＋CTX treatment,remission rate,adverse reactions of the 2 groups were compared.Results Effective rate of the ob-servation group was 83.78%,of the control group was 56.76%,the difference was statistically significant （chi-square=1.583,P=1.583）.Neurotoxicity and muscle joint pain probability of the observation group were higher than the control group ,the differ-ence was statistically significant（P〈0.05）;There had no statistically significant difference in hematocytopenia ,thrombocytopeni, nausea,vomiting,anemia,hair loss and abnormal liver function and the rate of allergic reaction of the 2 groups（P〉0.05）.Con-clusion Paclitaxel combined with anthracycline-based drugs ＋CTX scheme for advanced breast cancer is effective ,with more adverse reactions ,complications prevention measures should be done before and during treatment to prevent and reduce the com -plications.