阿那曲唑辅助治疗对绝经后乳腺癌患者血脂代谢的影响

The Effect of Anastrozole Adjuvant Therapy on Lipid Metabolism in Postmenopausal Patients with Breast Cancer

目的探讨阿那曲唑对绝经后乳腺癌患者血脂代谢的影响。方法选择绝经后乳腺癌患者273例。所有患者均服用阿那曲唑1 mg/次/d。患者于治疗前和治疗后3个月、6个月、12个月和以后每12个月空腹采集静脉血检测血清TC、TG、LDL-C和HDL-C水平。记录患者用药期间的不良反应。结果 TC和HDL-C的水平在治疗1年后开始显著升高,LDL-C的水平在治疗6个月后开始显著升高(P<0.05)。TC的水平变化与服药时间呈显著的正相关(P<0.05);TG的水平变化与年龄和BMI呈显著正相关,与服药时间呈显著负相关(P<0.05);LDL-C水平与年龄和服药时间呈显著正相关(P<0.05);HDL-C与绝经时间呈显著负相关,与BMI和服药时间呈显著正相关(P<0.05)。结论阿那曲唑治疗绝经后乳腺癌患者可影响患者的血脂代谢,临床在应用此药时应根据患者的自身情况定期检测血脂水平。

Objective To investigate the effect of anastrozole adjuvant therapy on lipid metabolism in postmenopausal patients with breast cancer .Methods Selected 273 cases of postmenopausal patients with breast cancer .All the patients were took anastrozole 1 mg/time/d.Patients before treatment and after treatment 3 months,6 months,12 months and every 12 months after the fasting blood were tested of serum TC ,TG,LDL-C and HDL-C levels,until the end of follow-up or treatment.Recorded adverse drug reactions during the administration of the patients .Results The level of TC and HDL-C increased significantly after 1 years of treatment,and the level of LDL-C increased significantly after 6 months（P〈0.05）.The TC level and the duration of treatment had significantly positive correlation （P〈0.05）;TG level changes with age and BMI had significantly positive correla-tion,and taking time showed a significant negative correlation （P〈0.05）;LDL-C levels and age and the duration of treatment was significantly positive correlation（P〈0.05）.HDL-C and the vast time had significantly negative correlation ,and BMI and medica-tion time showed significant positive correlation （P〈0.05）.Conclusion Anastrozole for postmenopausal breast cancer patients can affects lipid metabolism ,clinical application of the drug should be according to the patients ＆#39; regular testing blood lipid levels .