血清CA125联合超声评分对卵巢良恶性肿瘤的鉴别价值

The Value of the Serum CA125 Combined with Ultrasound Scoring in the Differential Diagnosis of Benign and Malignant Ovary Tumor

目的研究血清CA125联合超声评分鉴别卵巢良恶性肿瘤的价值。方法选择卵巢肿瘤患者200例,108例卵巢良性肿瘤患者为良性组,92例卵巢恶性肿瘤患者为恶性组,于术前一周行腹部超声联合阴道超声检查,进行Finkler超声评分,同时空腹抽取静脉血检测血清CA125水平。结果恶性组的Finkler评分和阳性率均明显高于良性组(P<0.05);恶性组的CA125水平和阳性率均明显高于良性组(P<0.05);Finkler评分联合CA125的特异度、敏感度、阴性预测值和阳性预测值均高于单一检测(P<0.05);Finkler评分联合CA125对Ⅰ~Ⅱ期卵巢癌的诊断阳性率明显高于单一检测方法(P<0.05),而对Ⅲ~Ⅳ期的诊断阳性率无明显差异(P>0.05)。结论血清CA125联合超声评分鉴别卵巢良恶性肿瘤具有较高的特异度和敏感度,优于单一检测方法,且对Ⅰ~Ⅱ期即早期卵巢癌具有更高的诊断价值。

Objective To investigate the value of the serum CA 125 combined with ultrasound scoring in the differential diagnosis of benign and malignant ovary tumor .Methods 200 cases of ovarian tumors were selected ,including 108 cases of be-nign tumors （ benign group ） ,and 92 cases of malignant tumors （ malignant group ） .All patients underwent abdominal ultrasound combined with transvaginal ultrasound .The contrast of Finkler ultrasound scores and serum CA 125 level were made .Results The ultrasound scores and positive rate ,serum CA125 level and positive rate of the malignant group were significantly higher than those of the benign group （P〈0.05）;Sensitivity,specificity,positive and negativepredictive values of Finkler ultrasound scores combined with serum CA125 were all significantly higher than single test （ P〈0.05）;diagnostic positive rate of Finkler ultra-sound scores combined with serum CA125 for stage Ⅰ~Ⅱovarian cancer were significantly higher than single test （P〈0.05）, but there had no significant difference for stageⅢ~Ⅳovarian cancer（P〉0.05）.Conclusion Ultrasound scores combined with serum CA125 in the differential diagnosis of benign and malignant ovary tumor have higher sensitivity and specificity ,it is better than single test ,and has higher diagnostic value in the diagnosis of stage Ⅰ~Ⅱovarian cancer .