局部晚期非小细胞肺癌调强放疗与三维适形放疗的对比

Contrast Study of Intensity-modulated Radiotherapy and Threedimensional Conformal Radiotherapy for Locally Advanced Non-small Cell Lung Cancer

目的探讨局部晚期非小细胞肺癌调强放疗与三维适形放疗的差异。方法收集我院局部晚期非小细胞肺癌患者,随机分为研究组(接受调强放疗)和对照组(接受三维适形放疗)。对比两组患者靶区剂量;两组治疗后临床缓解情况;两组平均生存期及1年生存率。结果两组患者平均剂量比较差异无统计学意义(P>0.05);两组患者靶区指数及靶区适形指数比较差异有统计学意义(P<0.05);两组治疗后临床缓解情况比较差异无统计学意义(P>0.05);两组平均生存期及1年生存率比较差异无统计学意义(P>0.05)。结论与三维适形放疗治疗局部晚期非小细胞肺癌相比,调强放疗疗效肯定,可降低正常器官的照射剂量。

Objective To investigate the difference between intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for locally advanced non-small cell lung cancer. Methods Patients with locally advanced non-small cell lung cancer in our hospital were randomly assigned to the study group （who received IMRT） and the control group （who received three dimensional conformal radiotherapy）. The target dose in the two groups was compared between the two groups after treatment, the median survival and the 1 year survival rate were compared between the two groups. Results There was no significant difference between the average dose of patients in the two groups （P 〉 0.05）. There was signifcant difference between the two group about target index and target area conformal index （P 〈 0.05）; after treatment, the difference about clinical remission had no signifcant difference between two groups （P 〉 0.05）; the mean survival and 1 year survival rate showed no significant difference （P 〉 0.05）. Conclusion Compared with three-dimensional conformal radiotherapy for locally advanced non-small cell lung cancer, IMRT is effective and can decrease the radiation dose of normal organs.