临床分离铜绿假单胞菌感染的分布与耐药性观察研究

Distribution and drug resistance of pseudomonas aeruginosa infection isolated from clinical specimens

目的:探讨临床分离铜绿假单胞菌感染的分布与耐药性。方法:对73例患者155株铜绿假单胞菌进行分离和研究,根据菌株药敏、来源结果,进行耐药性及菌株来源分布分析。结果:痰中检出铜绿假单胞菌的数量最多;神经内科是检出菌株最多的科室;铜绿假单胞菌对哌拉西林/他唑巴坦、氨曲南、头孢他啶、亚胺培南、替卡西林/克拉维酸、头孢吡肟的耐药率比较高,对庆大霉素、环丙沙星、左旋氧氟沙星和哌拉西林的耐药率比较低。结论:研究出高效的抗菌药物及高感染率科室,有利于预防铜绿假单胞菌感染,强化耐药性检测,能指导临床用药。

Objective：To explore the distribution and drug resistance of pseudomonas aeruginosa infection isolated from clinical specimens.Methods：A total of 155 pseudomonas aeruginosa strains were isolated and studied in 73 patients.Based on the drug sensitivity and source,we carried out the analysis of drug resistance and source distribution.Results：The number of pseudomonas aeruginosa detected in sputum was the largest.The detected strains were the most in neurology.The drug resistance rate of pseudomonas aeruginosa were high for piperacillin/tazobactam,aztreonam,ceftazidime,imipenem,ticarcillin/clavulanic acid,cefepime,the drug resistance rate of pseudomonas aeruginosa were low for gentamicin,ciprofloxacin,levofloxacin and piperacillin.Conclusion：Finding effective antimicrobial agents and high infection rates was beneficial to prevent pseudomonas aeruginosa infection.Strengthening drug resistance test can guide clinical medication.