奥曲肽联合兰索拉唑钠治疗急性消化道出血效果观察

Clinical observation of octreotide combined with lansoprazole sodium in the treatment of acute gastrointestinal hemorrhage

目的探讨奥曲肽联合兰索拉唑钠急诊治疗急性消化道出血的临床疗效。方法选取2014年6月至2015年6月,我院收治的接受急诊治疗急性消化道出血患者60例,随机分为观察组和对照组,每组30例。其中观察组患者采用奥曲肽联合兰索拉唑钠治疗,对照组患者单纯使用奥曲肽治疗,观察两组患者的止血时间、住院时间及治疗效果。结果观察组患者在止血时间和住院时间上明显短于对照组,差异具有统计学意义(P<0.05)。两组治疗总有效率的比较,观察组高于对照组,差异有统计学意义(P<0.05)。观察组中2例患者出现面色苍白、出汗等症状,予以滴速调整、对症治疗后好转;对照组中3例患者出现恶心、呕吐等症状,对症处理后缓解。两组患者均未出现严重不良反应。结论奥曲肽联合兰索拉唑钠急诊治疗急性消化道出血效果显著,止血速度快,并且安全可靠,不良反应少,有利于患者的疾病恢复,缩短了患者的住院时间,值得广泛使用。

Objective To invesligale the effecl of oclreolide combined with lansoprazole sodium for emergency Irealmenl of acule gaslroinleslinal hemorrhage. Methods From June 2014 lo June 2015, 60 cases of palienls wilh acule gaslroinleslinal hemorrhage in our hospilal for emergency lrealmenl were randomly divided inlo observalion group and conlrol group, wilh 30 palienls in each group. The observalion group was lrealed wilh oclreolide combined wilh lansoprazole sodium, while lhe conlrol group was lrealed wilh oclreolide only. The hemoslasis lime, ospilalizalion lime and lrealmenl effecls of lhe lwo groups were observed. Results The hemoslasis lime and hospilalizalion lime of lhe observalion group were significanlly shorler lhan lhose in lhe conlrol group, lhe differences were slalislically significanl （P 〈0.05）. The lolal effeclive rale of lhe observalion group was higher lhan lhal of lhe conlrol group, lhe difference was slalislically significanl （ P 〈0.05）. In lhe observalion group, 2 palienls presenled wilh pale, swealing and olher symploms, and lhey were improved afler adjusling lhe drip rale and symplomalic lrealmenl; in lhe conlrol group, 3 palienls had nausea, vomiling and olher symploms, and lhey were improved afler symplomalic lrealmenl. There were no serious adverse reaclions occurred in lhe lwo groups. Conclusion Oclreolide combined wilh lansoprazole sodium has significanl emergency lrealmenl for acule gaslroinleslinal hemorrhage. Il has shorl hemoslasis lime, and is safe and reliable wilh less adverse reaclion, which is conducive lo lhe palienl＇s disease recovery. Il can shorlen lhe palienls＇ hospilal slay, and is worlh being widely used.